Results 151 to 160 of about 4,732,020 (409)

Therapeutic Treatment of Superoxide Dismutase 1 (G93A) Amyotrophic Lateral Sclerosis Model Mice with Medical Ozone Decelerates Trigeminal Motor Neuron Degeneration, Attenuates Microglial Proliferation, and Preserves Monocyte Levels in Mesenteric Lymph Nodes [PDF]

, 2022
Michael Bette, Eileen Cors, Carolin Kresse, Burkhard Schütz   +3 more
openalex   +1 more source

Evaluation of magnetic resonance imaging guidelines for differentiation between thoracolumbar intervertebral disk extrusions and intervertebral disk protrusions in dogs [PDF]

, 2016
Four MRI variables have recently been suggested to be independently associated with a diagnosis of thoracolumbar intervertebral disk extrusion or protrusion.
Aikawa, Aikawa, Altman, Baltzer, Bergknut, Bergknut, Berknut, Besalti, Bos, Bray, Brisson, Brisson, Cihangiroglu, Cudia, da Costa, Decker, Decker, Decker, Downes, Fenn, Fisher, Flegel, Fleis, Gomes, Griffiths, Hansen, Knight, Landis, Lee, Macias, McKee, Modic, Moissonnier, Olby, Olby, Petersen, Rehman, Rihn, Robertson, Ruddle, Salger, Sander, Seiler, Sim, Smolders, Solgaard Sorensen, Song, Truszczyńska, Wie   +48 more
core   +1 more source

Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics

Advanced Biology, EarlyView.
This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim, Kanghoon Choi, Amy Lin, Jungkyu Kim   +3 more
wiley   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

The Common Antidiabetic Drug Metformin Reduces Odds of Developing Age-Related Macular Degeneration

Investigative Ophthalmology and Visual Science, 2019
Purpose AMD is the leading cause of irreversible blindness in older individuals in the Western world, and there are currently no therapies to halt disease progression.
Emily E. Brown, Jacob D. Ball, Zhaoyi Chen, G. Khurshid, M. Prosperi, J. Ash   +5 more
semanticscholar   +1 more source

Extracorporeal Catalytic Hemoperfusion Therapy for Refractory Septic Shock Using Ceria Nanoparticle‐Embedded Porous Microbeads

Advanced Functional Materials, EarlyView.
This study introduces an extracorporeal hemoperfusion system incorporating porous microbeads embedded with autocatalytic ceria nanoparticles (CeNPs) for targeted reactive oxygen species (ROS) scavenging in septic shock. The blood‐compatible hemoperfusion cartridge demonstrated significant improvements in survival, hemodynamic stability, and organ ...
Pilseon Im, Han‐Gil Jeong, Donghee Kim, Jimin Song, Ngoc Man Phan, Eun‐seo Choi, Young‐Min Kim, Seo‐Hyeon Jeong, Jooho Park, Inwon Park, Jaeyun Kim   +10 more
wiley   +1 more source

Combination of cGMP analogue and drug delivery system provides functional protection in hereditary retinal degeneration

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Development of treatments for hereditary degeneration of the retina (RD) is hampered by the vast genetic heterogeneity of this group of diseases and by the delivery of the drug to an organ protected by the blood–retina barrier.
E. Vighi, D. Trifunović, P. Veiga-Crespo, A. Rentsch, Dorit Hoffmann, A. Sahaboglu, T. Strasser, M. Kulkarni, E. Bertolotti, A. van den Heuvel, T. Peters, A. Reijerkerk, Thomas Euler, M. Ueffing, F. Schwede, H. Genieser, P. Gaillard, V. Marigo, P. Ekström, François Paquet-Durand   +19 more
semanticscholar   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Polyethylene microplastics promote nucleus pulposus cell senescence by inducing oxidative stress via TLR4/NOX2 axis

Ecotoxicology and Environmental Safety
This study aimed to detect and characterize microplastics in intervertebral disc and investigate their effects and molecular mechanism on intervertebral disc degeneration.
Weilin Zhang, Zhencong Li, Zhongwei Wang, Kuize Liu, Shengbang Huang, Jinguo Liang, Zhiwen Dai, Weixiong Guo, Chao Mao, Siyuan Chen, Jinsong Wei   +10 more
doaj  

Review of gene therapies for age-related macular degeneration

Eye, 2022
A. Khanani, M. J. Thomas, A. Aziz, Christina Y. Weng, Carl J. Danzig, Glenn Yiu, S. Kiss, N. Waheed, P. Kaiser   +8 more
semanticscholar   +1 more source