Results 161 to 170 of about 4,732,020 (409)

In vivo evidence for NMDA receptor mediated excitotoxicity in a murine genetic model of Huntington Disease [PDF]

, 2008
N-methyl-D-aspartate receptor (NMDAR) mediated excitotoxicity is implicated as a proximate cause of neurodegeneration in Huntington Disease (HD). However, this hypothesis has not been tested rigorously in vivo. NMDAR NR2B-subunits are the predominant NR2
Joe Tsien, Mary Heng, Peter Detloff, Phillip Wang, Roger Albin   +4 more
core   +1 more source

Microbubble‐Controlled Delivery of Biofilm‐Targeting Nanoparticles to Treat MRSA Infection

Advanced Functional Materials, EarlyView.
Here, an effective strategy using microbubble (MB)‐controlled delivery of biofilm‐targeting nanoparticles (BTNs) for removal and therapy of methicillin‐resistant Staphylococcus aureus (MRSA) biofilm infections is introduced. In vivo delivery of MB with BTN is demonstrated to silence key bacterial genes involved in biofilm formation (icaA), bacterial ...
Ju Yeon Chung, Yujin Ahn, Joo Hun Lee, Seungju Yang, Seung Cheol Lee, Hyunjoon Kong, Hyun Jung Chung   +6 more
wiley   +1 more source

Biomarkers of optical coherence tomography in evaluating the treatment outcomes of neovascular age-related macular degeneration: a real-world study

Scientific Reports, 2019
This study evaluated the characteristic changes in optical coherence tomography (OCT) biomarkers in neovascular age-related macular degeneration (nAMD) treated with anti-vascular endothelial growth factor drugs and their relationship with visual outcomes
Tso-Ting Lai, Y. Hsieh, Chung-May Yang, T. Ho, Chang-Hao Yang   +4 more
semanticscholar   +1 more source

Controlled Release of Human Dental Pulp Stem Cell‐Derived Exosomes from Hydrogels Attenuates Temporomandibular Joint Osteoarthritis

Advanced Healthcare Materials, EarlyView.
Exosomes can reduce tissue damage in temporomandibular joint osteoarthritis (TMJOA), but rapid clearance limits their efficacy. This study encapsulates exosomes in hyaluronic acid hydrogels for controlled release. In a rat model, hydrogel‐encapsulated exosomes outperform free exosomes in preserving bone integrity and reducing tissue destruction ...
Victor Diez‐Guardia, Yajing Tian, Yunzhe Guo, Jiaying Li, Shengjie Cui, Cécile A. Dreiss, Eileen Gentleman, Xuedong Wang   +7 more
wiley   +1 more source

Mild hyperthermia enhanced synergistic uric acid degradation and multiple ROS elimination for an effective acute gout therapy

Journal of Nanobiotechnology
Background Acute gouty is caused by the excessive accumulation of Monosodium Urate (MSU) crystals within various parts of the body, which leads to a deterioration of the local microenvironment.
Pei Zhao, Hua-Zhong Hu, Xiao-Tong Chen, Qi-Yun Jiang, Xue-Zhao Yu, Xiao-Lin Cen, Shi-Qing Lin, Sui-qing Mai, Wei-lin Pang, Jin-Xiang Chen, Qun Zhang   +10 more
doaj   +1 more source

Significance of the Association between Disc Degeneration Changes on Imaging and Low Back Pain: A Review Article

Asian Spine Journal, 2019
Low back pain (LBP) is a major health issue resulting in a huge economic burden on the community. It not only increases the medical costs directly, but also raises the disability and loss of productivity in the general population.
A. Rahyussalim, Muhammad Luqman Labib Zufar, T. Kurniawati   +2 more
semanticscholar   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

Low-Dose Aspirin and Medical Record–Confirmed Age-related Macular Degeneration in a Randomized Trial of Women [PDF]

, 2009
William G. Christen, Robert J. Glynn, Emily Y. Chew, Julie E. Buring   +3 more
openalex   +1 more source

The Multi-Modal Risk Analysis and Medical Prevention of Lumbar Degeneration, Fatigue, and Injury Based on FEM/BMD for Elderly Chinese Women Who Act as Stay-Home Grandchildren Sitters [PDF]

, 2021
Na Li, María José Cavagnaro, Kun Xiong, Xianping Du, Jian Shi   +4 more
openalex   +1 more source

Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration

Science Advances, 2019
Angpt-Tie2 is essential for choriocapillary maintenance, and Tie2 activation could be a therapeutic avenue for fundamental treatment of NV-AMD. Choriocapillary loss is a major cause of neovascular age-related macular degeneration (NV-AMD).
Jaeryung Kim, J. Park, Jeongwoon Choi, Intae Park, Y. Hwang, Hosung Bae, Yongjoo Kim, WooJhon Choi, Jee Myung Yang, Sangyeul Han, Tae-Young Chung, Pilhan Kim, Y. Kubota, H. Augustin, W. Oh, G. Koh   +15 more
semanticscholar   +1 more source