Results 211 to 220 of about 546,188 (282)

Decoding Dental Stem Cell Aging: Mechanisms, Therapeutic Strategies, and Beyond

Advanced Science, EarlyView.
Dental stem cell (DSC) aging involves genomic instability, mitochondrial dysfunction, telomere attrition, and epigenetic alterations, leading to impaired proliferation, reduced differentiation potential, and pro‐inflammatory secretory activity. These processes drive cellular senescence and compromise regenerative and immunomodulatory functions, thereby
Xinyuan Zhao, Yunfan Lin, Pei Lin, Ye Lu, Jiarong Zheng, Xu Chen, Zihao Zhou, Li Cui   +7 more
wiley   +1 more source

Identification of Core Senescence-Related Genes and Characterization of Comprehensive Immune Landscape in Intervertebral Disc Degeneration. [PDF]

Int J Genomics
Xu Q, Lian Z, Wang A, Li D, Wang Y, Guo Y, Qin J, Wang J, Zhao S.   +8 more
europepmc   +1 more source

Epidemiology of Age-Related Macular Degeneration in the Republic of Bashkortostan (Clinical and Statistical Analisys of the “Ural Eye and Medical Study”)

, 2019
Timur R. Gilmanshin
openalex   +2 more sources

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

Advanced Science, EarlyView.
Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu, Tan Wu, Larry Tso‐Lun Lo, Chi‐Chiu Ko, Xin Wang, Chi Him Eddie Ma   +5 more
wiley   +1 more source

Hypertrophic olivary degeneration secondary to brain abscess: a case report and literature review. [PDF]

Front Hum Neurosci
Tian S, Tang B, Zhang K, Tian X, Hu N.
europepmc   +1 more source

What\u27s new in spine surgery [PDF]

, 2003
Anderson, Paul A., Boden, Scott D., Bridwell, Keith H., Vaccaro, Alexander R., Zigler, Jack E.   +4 more
core   +2 more sources

Deoxynivalenol Exposure Leads to Abnormal Renal Tubular Autophagy Flow

Advanced Science, EarlyView.
DON exposure disrupts the initiation of renal autophagy by inhibiting the formation of autophagosomes, thereby impairing mitochondrial degradation. Damaged mitochondria increase oxidative stress, reduce ferroptosis resistance, and cause lysosomal Fe2⁺ accumulation, further disrupting autophagy.
Hao Chen, Xintong Zhou, Jun Ma
wiley   +1 more source

Therapeutic potential of IκB kinase epsilon inhibition in preventing meniscal degeneration of early osteoarthritis. [PDF]

Bone Joint Res
Hirose R, Akasaki Y, Kuwahara M, Uchida T, Hyodo Y, Sakai M, Kita T, Kurakazu I, Lotz MK, Nakashima Y.   +9 more
europepmc   +1 more source

BLOC1S1 Attenuates B. Melitensis 16M LPS‐Triggered Autophagy by Spatial Confinement of TDP‐43

Advanced Science, EarlyView.
This study explores how B. melitensis 16M LPS and BLOC1S1 regulate autophagy in goat spermatogonial stem cells. The 16M LPS is activating AMPK‐dependent autophagy, increasing LC3B‐II/I ratios and lysosomal genes, while Escherichia coli LPS shows no effect.
Shicheng Wan, Miao Han, Mengfei Zhang, Wenbo Chen, Fangde Xie, Xuan Luo, Wenping Wu, Congliang Wang, Donghui Yang, Bin Han, Haijing Zhu, Haisheng Yu, Na Li, Jinlian Hua   +13 more
wiley   +1 more source

Can Laser Retinopexy Prevent Retinal Detachment in Asymptomatic, High-Risk Eyes? [PDF]

Clin Ophthalmol
Morris RE, Sapp MR, Conn DR, Chawla H, Kuhn F.   +4 more
europepmc   +1 more source