Results 221 to 230 of about 546,188 (282)

Plant Virus‐Induced Inheritable Apoptosis Drives Reproductive Costs in Female Insect Vectors to Balance Viral Biparental Transmission

Advanced Science, EarlyView.
Rice gall dwarf virus (RGDV), transmitted biparentally by leafhopper vector to their offspring, exploits the capsid protein to induce inheritable ovarian apoptosis via insulin‐driven PI3K/AKT/FoxO signaling axis. This mechanism enhances infection but reduces female reproductive fitness, causing inefficient maternal transmission.
Haibo Wu, Wenqiang Wan, Qingquan Liang, Hengsong Yang, Chengcong Lu, Taiyun Wei, Qian Chen   +6 more
wiley   +1 more source

Case Report: Giant hydropic leiomyoma of the uterus presenting as an aggressive abdominopelvic tumor. [PDF]

Front Oncol
Giannios K, Anestiadou E, Liampou E, Spilioti LK, Bakaloudi DR, Papadopoulos V.   +5 more
europepmc   +1 more source

The Study of Crime and Degeneration from a Medical Standpoint

, 1897
Willis S. Anderson
openalex   +2 more sources

A multi-paradigm, whole system view of health and social care for age-related macular degeneration

, 2012
Brailsford, S.C., Channon, Andrew A.R., Lotery, Andrew, Rossiter, Stuart P., Viana, Joe   +4 more
core   +1 more source

A Resistive Soft Robotic Exosuit for Dynamic Body Loading in Hypogravity

Advanced Science, EarlyView.
The resistive hypogravity exosuit is a lightweight wearable robotic exosuit that uses pneumatic artificial muscles to restore Earth‐like metabolic and muscular demands during locomotion in low gravity. Tested on healthy subjects in Earth and simulated Moon gravity, the suit restores energy expenditure and muscle activation without altering gait ...
Emanuele Pulvirenti, Richard Suphapol Diteesawat, Gaspare Pavei, Valentina Natalucci, Helmut Hauser, Alberto Minetti, Jonathan Rossiter   +6 more
wiley   +1 more source

Author Correction: Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors

Nature Communications
Wei Xia, Jing Xie, Zhiqing Cai, Xuhua Liu, Jing Wen, Zhong-Kai Cui, Run Zhao, Xiaomei Zhou, Jiahui Chen, Xinru Mao, Zhengtao Gu, Zhimin Zou, Zhipeng Zou, Yue Zhang, Ming Zhao, Maegele Mac, Qiancheng Song, Xiaochun Bai   +17 more
doaj   +1 more source

Lactate Activates the HCAR1/β‐Arrestin2/PP2A Signaling Axis to Mediate STAT1/2 Dephosphorylation and Drive Osteosarcoma Progression

Advanced Science, EarlyView.
In the present study, it is found that in osteosarcoma, lactate‐activated HCAR1 promotes β‐arrestin 2 translocation from cytoplasm to nucleus. In the nucleus, β‐arrestin 2 recruits PP2A to the activated STAT1/2 dimers, mediating STAT1/2 dephosphorylation and inhibiting the transcription of downstream anti‐oncogenes to promote OS progression.
Zhitao Han, Qi Jia, Guangjian Bai, Zhao Li, Jin Zeng, Zhenhua Wang, Jing Zhang, Jiashi Cao, Baoquan Xin, Yonggang Liu, Jingyu Shen, Lining Wang, Xing Huang, Chunlei Zhang, Kai Tong, Fenglei Dai, Yajie Zhang, Weina Zhu, Songyi Cheng, Yuanming Chen, Xinghai Yang, Guanghui Chen, Zhenhua Zhou, Yong Ma, Weibo Liu, Ting Wang, Tielong Liu   +26 more
wiley   +1 more source

PDC-DETR: a Parallel Dilated Convolutional Detection Transformer for preliminary screening of multiple macular degeneration. [PDF]

BMC Med Imaging
Wang Y, Wei W, Pei X, Zhan H, Tang Y, Li Y, Bai J, Li J.   +7 more
europepmc   +1 more source

Inhibition of Hypersialylation in Human Intervertebral Disc Degeneration Modulates Inflammation and Metabolism

Advanced Science, EarlyView.
Glycosylation, specifically hypersialylation, is identified as a critical factor in human intervertebral disc (IVD) degeneration—a major cause of low back pain. This study demonstrates that inhibiting sialylation reduces inflammation and oxidative stress in IVD tissues, suggesting new therapeutic possibilities.
Kieran Joyce, Aert F. Scheper, Aung Myat Phyo, Roisin O’ Flaherty, Richard Drake, Aiden Devitt, Martina Marchetti‐Deschmann, Radka Saldova, Abhay Pandit   +8 more
wiley   +1 more source

RIPK3 is spatially associated with cartilage degeneration in osteoarthritis: integrative transcriptomic and histological analysis. [PDF]

J Orthop Surg Res
Wang L, Tang J, Niu L, Li Z, Wu L, Zhao W, Wang G.   +6 more
europepmc   +1 more source