Results 251 to 260 of about 4,718,303 (380)

Gender as Pathology: Disease, Degeneration, and Medical Discourse in Late Nineteenth-century Colombia

, 2012
Hanni Jalil Paier
openalex   +2 more sources

AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells

Advanced Science, EarlyView.
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu, Guisheng Chen, Rui Hu, Peiwen Liu, Jintao Lou, Wenji Zhao, Zuhong He, Suhua Sha, Yiqing Zheng   +8 more
wiley   +1 more source

Risk of age-related macular degeneration according to the chronic kidney disease and proteinuria in Korea: a 10-year nationwide cohort study. [PDF]

Sci Rep
Park J, Han K, Kim B, Lee K, Jang HR, Yoon JM, Lim DH, Shin DW.   +7 more
europepmc   +1 more source

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

Cost-Effectiveness Analysis of Surgical Strategies Versus Medical Management for Rheumatic Heart Disease in Rwanda. [PDF]

J Am Heart Assoc
Mlambo V, Wang S, Musoni M, Rando H, Ingabire L, Patton-Bolman C, Mukeshimana G, Ntaganda E, Bolman R, Bendavid E, Lin Y.   +10 more
europepmc   +1 more source

The Use of Medical Apparatus of THz-Therapy “Ka Ve Tche-O2-Orbit” on 129.0 GHz on Molecular Spectrum of Radiation and Absorbation of Atmospheric Oxygen in Healthy Volunteers and in Patients with Involutional Macular Degeneration

, 2013
В. Ф. Киричук, L. E. Fedorischeva, K. U. Eremenko, Anatolya F. Cypyaschuk, Е. В. Понукалина, А. А. Цымбал, Irina V. Smychlyaeva, О. Н. Антипова, Т. С. Великанова, Е. С. Оленко, Л. К. Токаева, Natalia E. Babichenko   +11 more
openalex   +2 more sources

Consequences and Mechanisms of Noise‐Induced Cochlear Synaptopathy and Hidden Hearing Loss, With Focuses on Signal Perception in Noise and Temporal Processing

Advanced Science, EarlyView.
Noise‐induced synaptopathy (NIS) is largely reversible due to self‐repair. NIS and noise‐induced hidden hearing loss are two concepts with similarities and differences. The major hearing deficits in NIHHL are temporal processing disorders. The translation of animal data in NIS studies to humans is hindered by many factors.
Hui Wang, Steven J Aiken, Jian Wang
wiley   +1 more source

Frontotemporal Lobar degeneration with TDP-43 presenting as progressive supranuclear palsy syndrome. [PDF]

Acta Neuropathol Commun
Murakami A, Koga S, Sekiya H, Nakamura M, Yakushiji Y, Dickson DW.   +5 more
europepmc   +1 more source

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, EarlyView.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source

Targeting advanced glycation end products: potential therapeutic approaches for mitigating diabetic intervertebral disc degeneration? [PDF]

Front Endocrinol (Lausanne)
Wang L, Shao Q, Wu H, Li C.
europepmc   +1 more source