Results 261 to 270 of about 559,157 (325)

Atypical Retinitis Pigmentosa With Macular Sparing in a Patient With Compound Heterozygous <i>ABCA4</i> Variants: A Case Report and Diagnostic Challenge. [PDF]

Clin Case Rep
Li N, Dang Y.
europepmc   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Economic and Medical Burden of Non-Exudative Age-Related Macular Degeneration in Germany: A Retrospective Observational Claims Data Study

Alexander Schuster, Lilia Leisle, Nils Picker, Hanne Vorwerk, Philipp Hahn, Jürgen Wasem, Philip Lewis   +6 more
openalex   +2 more sources

Correlation of morphological parameters of disc degeneration with magnetic resonance imaging in cases of discogenic axial low back pain in a hospital setting in Kinshasa: case of the center medical Diamond [PDF]

Djo Iyoto Mbo M., Jean Mukaya Tshibola, Stéphane Yanda Tongo, Désiré Mukanga yaya, Dady Liombo mboso, Guillain Nsonde Nsiku, Lys Makwanza, Joseph Kombo kiese, Rama Mputu bentuen   +8 more
openalex   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Molecular insights into Atorvastatin's role in delaying intervertebral disc degeneration. [PDF]

Front Cell Dev Biol
Li Y, Wang L, Wang X, Li K, Wang Q, Gao K, Zhang C, Lv C.   +7 more
europepmc   +1 more source

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

Severe bilateral retinal degeneration following a twenty-six-year pentosan polysulfate sodium exposure: a case report. [PDF]

Am J Ophthalmol Case Rep
Zhao AT, Wibbelsman TD, Calotti M, Richards CJ, Vrabec TR.   +4 more
europepmc   +1 more source

Auditory Hair Cell Mechanotransduction Channels Dynamically Shape the Mechanical Properties of Their Membrane Environment

Advanced Science, EarlyView.
This work shows, for the first time, that the stereocilia membrane in cochlear hair cells is dynamically regulated by the mechanotransduction channel to impact the membrane mechanical properties. This work provides direct evidence that the opening and closing associated with the MET channel is regulating the membrane viscosity suggesting that the MET ...
Shefin S. George, Anthony J. Ricci
wiley   +1 more source