Results 261 to 270 of about 549,632 (363)

Post‐Translational Modifications in Cilia and Ciliopathies

Advanced Science, EarlyView.
This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley   +1 more source

Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia‐Inducible Factor‐1 Signaling Pathway

Advanced Science, EarlyView.
This study investigates the role of macrophage pyruvate carboxylase (PC) in atherosclerosis (AS) demonstrating that PC upregulation in macrophages promotes metabolism reprogramming to enhance inflammatory responses via the HIF‐1 signaling pathway.
Ling‐Na Zhao, Rui‐Ling Wang, Ran‐Xin Liu, Meng‐Ru Zheng, Li Zhao, Bao‐Feng Li, Jia‐Le Li, De‐Shen Liu, Xiao‐Xia He, Qin‐Bao Peng, Kai Li, Tian‐Xiao Lin, Ying‐Ying Liu, Sheng‐Ping He, Jun Lu, Shao‐Yi Zheng, Xiu Liu, Fang‐Ze Huang   +17 more
wiley   +1 more source

Tracing global progress: two decades of age-related macular degeneration research. [PDF]

Int J Ophthalmol
Yuan LY, Li LP, Hua X, Yuan XY.
europepmc   +1 more source

LncRNA‐MEG3 Regulates Muscle Mass and Metabolic Homeostasis by Facilitating SUZ12 Liquid–Liquid Phase Separation

Advanced Science, EarlyView.
This study has identified lncRNA‐MEG3 as a key regulator of muscle mass, promoting slow‐twitch muscle fibers and preventing muscle atrophy. By stabilizing the SUZ12/PRC2 complex through liquid–liquid phase separation (LLPS), lncRNA‐MEG3 influences mitochondrial function and lipid metabolism.
Yilong Yao, Chao Yan, Haibo Huang, Shilong Wang, Jiaying Li, Yun Chen, Xiaolu Qu, Qi Bao, Lingna Xu, Yuanyuan Zhang, Danyang Fan, Xia He, Yanwen Liu, Yongsheng Zhang, Yalan Yang, Zhonglin Tang   +15 more
wiley   +1 more source

Developing a Deep Learning Radiomics Model Combining Lumbar CT, Multi-Sequence MRI, and Clinical Data to Predict High-Risk Adjacent Segment Degeneration Following Lumbar Fusion: A Retrospective Multicenter Study. [PDF]

Global Spine J
Zou C, Wang T, Wang B, Fei Q, Song H, Zang L.   +5 more
europepmc   +1 more source

Version 3 of the National Alzheimer’s Coordinating Center’s Uniform Data Set [PDF]

, 2018
al., et, Besser, Lilah, Morris, John C.
core   +1 more source

Electrically Tunable Momentum Space Polarization Singularities in Liquid Crystal Microcavities

Advanced Science, EarlyView.
Using a highly birefringent material embedded in a liquid crystal microcavity, the Rashba‐Dresselhaus resonance is obtained. In this regime, polarization singularities, known as C‐points, are observed in momentum space. The positions of these singularities can be modified by applying an external voltage to the sample.
Przemysław Oliwa, Piotr Kapuściński, Maria Popławska, Marcin Muszyński, Mateusz Król, Przemysław Morawiak, Rafał Mazur, Wiktor Piecek, Przemysław Kula, Witold Bardyszewski, Barbara Piętka, Helgi Sigurðsson, Jacek Szczytko   +12 more
wiley   +1 more source

Synergistic Modulating of Mitochondrial Transfer and Immune Microenvironment to Attenuate Discogenic Pain

Advanced Science, EarlyView.
Gallic acid (GA) and copper ions self‐assemble to form nanoparticles, which are then modified with mitochondrial targeting peptides and gap junction modulator. These nanoparticles scavenge mitochondrial reactive oxygen species to induce M2 polarization and enhance intercellular mitochondrial transfer.
Xinzhou Wang, Zhenyu Guo, Linjie Chen, Jing Sun, Kenny Yat Hong Kwan, Morgan Jones, Yan Michael Li, Yangyang Hu, Xueqiang Wang, Pooyan Makvandi, Xiangyang Wang, Qiuping Qian, Yunlong Zhou, Aimin Wu   +13 more
wiley   +1 more source

Correlation analysis of spine-pelvis parameters and age with lumbar paravertebral muscle degeneration in middle age and older adults. [PDF]

Am J Transl Res
Xu W, Zhang N, Li J, Meng X.
europepmc   +1 more source