Results 271 to 280 of about 546,188 (282)

Prevalence and associated factors of age-related macular degeneration in a Russian Population. The Ural Eye and Medical Study

, 2019
Rinat M. Zainullin, Mukharram M. Bikbov, Timur R. Gilmanshin, Gyulli M. Kazakbaeva, Ellina M. Rakhimova, Kamilla Safiullina, Songhomitra Panda‐Jonas, Iulia A. Rusakova, Natalia I. Bolshakova, Guzel Bikbova, Jost B. Jonas   +10 more
openalex   +1 more source

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

Advanced Science, EarlyView.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang, Yanran Zhang, Jialin Si, Honghui Mao, Feng He, Jin Ning, Guaiguai Ma, Xiaohua Chen, Haoxiang Xiao, Yuanyuan Zhu, Haifeng Zhang, Yifan Lu, Qian Liu, Meng Nian, Shiquan Sun, Shibin Yu, Shengxi Wu, Ze Fan, Zuolin Jin, Jing Huang   +19 more
wiley   +1 more source

Lovastatin-Loaded Nanoparticles in a Thermosensitive Chitosan Hydrogel as a Sustained Release System for Treating Intervertebral Disc Degeneration: In Vitro Cell Culture Study and In Vivo Evaluation Using a Needle-Puncture Induced Degeneration Model in Rat Caudal Discs. [PDF]

JOR Spine
Chen CW, Cheng YH, Yang KC, Huang CC, Hu MH, Sun YH, Wang JL, Yang SH.   +7 more
europepmc   +1 more source

Therapeutic Reprogramming of Glioblastoma Phenotypic States Using Multifunctional Heparin Nanoparticles

Advanced Science, EarlyView.
This study presents heparin‐derived nanoparticles (HP‐NPs) as a novel precision medicine platform that combines therapeutic and delivery functions. HP‐NPs target drug‐resistant glioblastoma stem cells, reprogramming them into a drug‐sensitive phenotype and significantly reducing tumor progression.
Vadim Le Joncour, Austin D. Evans, Camilla Karoliina Bergström, Vignesh Kumar Rangasami, Sumanta Samanta, Nithiyanandan Krishnan, Yuji Teramura, Bo Nilsson, Patricia Hedenqvist, Elin Manell, Jons Hilborn, Marianne‐Jensen Waern, Oommen P. Varghese, Pirjo Laakkonen, Oommen P. Oommen   +14 more
wiley   +1 more source

Generating a Preclinical Model for PITPNM3 and Evaluating Genotype-Phenotype Concordance: Insights from a Mouse Model. [PDF]

Cells
Demirkol A, Li J, Tsang SH.
europepmc   +1 more source

Exploring mean kurtosis in MR diffusion kurtosis imaging for early detection of lumbar spine degeneration: a systematic review. [PDF]

F1000Res
Barnes NA, Dkhar W, Kadavigere R, Sukumar S, Pradhan A, P S P, K V.   +6 more
europepmc   +1 more source

Case Report: Simultaneous mucoid degeneration of the ACL and PCL in a 62-year-old man: an under-recognized diagnostic pitfall. [PDF]

Front Surg
Shin KH, Jang IT, Han SB.
europepmc   +1 more source

Successful valve-in-valve transcatheter mitral valve replacement with neuroprotection in decompensated heart failure due to severe bioprosthesis degeneration. [PDF]

Postepy Kardiol Interwencyjnej
Słaba M, Bałys M, Kułach A, Wojakowski W, Smolka G.   +4 more
europepmc   +1 more source