Results 281 to 290 of about 559,157 (325)

Machine Learning Identifies Key Cells and Therapeutic Targets in Intervertebral Disc Degeneration: SASP-Driven Matrix Catabolism, Inflammation Amplification, and Metabolic Collapse. [PDF]

Inflammation
Kang Y, Li M, Hu B, Lv Y, Du J, Zhang D, Zhou H, Feng S.   +7 more
europepmc   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Pregnancy Complicated by Ruptured Degenerating Leiomyoma and Hemoperitoneum: Case Report. [PDF]

Clin Med Insights Case Rep
Farshidfar B, Shabankhani K, Mohammadi N, Ebadi Jamkhane A, Esfahani M.   +4 more
europepmc   +1 more source

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy

Advanced Science, EarlyView.
This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao, Qingqing Zhou, Mengli Li, Wen Zou, Zhenzhong Zhang, Jinjin Shi, Junjie Liu   +6 more
wiley   +1 more source

Causal Association Between Psoriasis and Age-Related Macular Degeneration: A Two-Sample Mendelian Randomization Study. [PDF]

Genes (Basel)
Lee Y, Kim S, Seo JH.
europepmc   +1 more source

Limitations of Obtaining Medical Information about Age-Related Macular Degeneration from Artificial Intelligence Chatbots

Dong Gyu Na, Yi Sang Yoon, Jae Hui Kim
openalex   +2 more sources

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

Unique liver function in high myopia: associations with myopic macular degeneration. [PDF]

BMC Ophthalmol
Pei Y, Meng J, He W, Zhang K, Guo D, Lu Y, Zhu X.   +6 more
europepmc   +1 more source

Reducing Hallucinations in Medical AI: A Knowledge Graph-Augmented Retrieval System for Evidence-Based Age-Related Macular Degeneration Information

Alexandru Lecu, Adrian Groza, Lezan Hawizy   +2 more
openalex   +1 more source

Biomechanical rational for development of cervical kyphosis deformity: a finite element analysis. [PDF]

BMC Musculoskelet Disord
Jin F, Li J, Liu Z, Liu B, Yang Z, Huang J.   +5 more
europepmc   +1 more source