Results 301 to 310 of about 4,718,303 (380)

The Pre-Catching Sperm Technique Increases the Efficiency of the Intracytoplasmic Sperm Injection Method by Improving Fertilization and Blastocyst Formation Rates. [PDF]

J Clin Med
Haering C, Manvelyan E, Coyne K, Hyams LA, Hamrick J, Findley J, Weinerman R, Flyckt R, Kim ST.   +8 more
europepmc   +1 more source

PP2Acα Deficiency in Vascular Smooth Muscle Cells Accelerates Aortic Aneurysm and Dissection by Regulating KLF4 Phosphorylation and Ubiquitination

Advanced Science, EarlyView.
Vascular smooth muscle cells (VSMCs)‐specific deficiency of PP2Acα exacerbates aortic aneurysm and dissection (AAD) by promoting phenotypic switching through AKT1‐mediated phosphorylation and stabilization of Kruppel‐like factor 4 (KLF4). Reduced PP2Acα enhances KLF4 ubiquitination resistance, suppressing VSMC contractile genes and accelerating aortic ...
Wei‐Peng Hu, Ze‐Yu Cai, Qing‐Le Li, Tao Zhang, Xiang‐Yu Chu, Chang Wang, Qing‐Yi Zhang, Rong Qi   +7 more
wiley   +1 more source

A pathway to sight. [PDF]

Elife
Wert KJ.
europepmc   +1 more source

Mechanical Forces Guide Axon Growth through the Nigrostriatal Pathway in an Organotypic Model

Advanced Science, EarlyView.
Nano‐pulling is a magnetic nanoparticle‐based technology for guiding and promoting the axon growth of induced pluripotent stem cell‐derived dopaminergic neurospheres in vitro or neural progenitors transplanted in the brain tissue. Fine control of axon guidance is essential for reconstructing neural networks and restoring functional connectivity in the ...
Sara De Vincentiis, Elena Capitanini, Karen Kira, Claudia Dell'Amico, Jun Takahashi, Marco Onorati, Fabian Raudzus, Vittoria Raffa   +7 more
wiley   +1 more source

Ophthalmologic Manifestations in Bardet-Biedl Syndrome: Emerging Therapeutic Approaches. [PDF]

Medicina (Kaunas)
Rosado A, Rodriguez E, Izquierdo N.
europepmc   +1 more source

Identifying Myeloid‐Derived Suppressor Cells and Lipocalin‐2 as Therapeutic Targets for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Inflammatory dysregulation drives intervertebral disc degeneration via stage‐dependent immune cellular dynamics. Single‐cell transcriptomics and genetic risk mapping revealed a shift from LCN2high myeloid‐derived suppressor cells maintaining disc repair in early stages to IL1B+ macrophage‐dominated pathology in advanced disease.
Changmeng Zhang, Haoyun Li, Hongfei Wang, Liangyu Shi, Ying Shing Chan, Yu Wang, Graham Ka Hon Shea   +6 more
wiley   +1 more source

The impact of lipidome on intervertebral disk degeneration, low back pain, and sciatica: a Mendelian randomization study. [PDF]

Sci Rep
Pang ZY, Zhu YB, Hu JX, Li XX, Gao YJ, Wang YY, Zhou Q, Li P.   +7 more
europepmc   +1 more source

Regional Hypoperfusion Predicts White Matter Tract Degeneration in Recent Single Subcortical Infarcts. [PDF]

J Am Heart Assoc
Yan Y, Zhang A, Zhang K, Jiang S, Hong L, Ye C, Cao L, Yang T, Hu Y, Pan R, Li C, Wu S, Cheng X, Wu B.   +13 more
europepmc   +1 more source

SARM1 loss protects retinal ganglion cells in a mouse model of autosomal dominant optic atrophy. [PDF]

J Clin Invest
Ding C, Ndiaye PS, Campbell SR, Fry MY, Gong J, Wienbar SR, Gibbs W, Morquette P, Chao LH, Do MTH, Schwarz TL.   +10 more
europepmc   +1 more source

The burden of age-related macular degeneration and its socioeconomic associates in the Eastern Mediterranean Region from 1990 to 2021. [PDF]

Sci Rep
Davari A, Piroozkhah M, Iranpour A, Nejadghaderi SA.   +3 more
europepmc   +1 more source