Evaluation of a nutritional supplement for the alleviation of pain associated with feline degenerative joint disease: a prospective, randomized, stratified, double-blind, placebo-controlled clinical trial. [PDF]
J Feline Med Surg, 2022 Cunningham R +3 more
europepmc +1 more source
Advanced Science, EarlyView.When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu +5 more
wiley +1 more source
Impact of age on degenerative joint disease of the temporomandibular joint: A systematic review and meta-analysis. [PDF]
Medicine (Baltimore)Wu Z, Lin Y, Lin Y.
europepmc +1 more source
JOINT PUB 1-01.1 1999 (OBSOLETE) : Compendium of Joint Publications.
, 2009 This publication provides a readily available list of all joint publications and a brief synopsis of each. Included is an overview of joint doctrine development, all promulgated joint publications, all joint publications currently under development, and ...
Joint Staff
core
Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents
Advanced Intelligent Discovery, EarlyView.This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer +3 more
wiley +1 more source
Proteomic profiling of serum in cats with naturally occurring degenerative joint disease and co-morbid conditions. [PDF]
Front Pain Res (Lausanne)Lascelles BDX +3 more
europepmc +1 more source
Advanced Intelligent Systems, EarlyView.A unifying device–cardiovascular interface framework is presented to classify implantable cardiovascular technologies as intracardiovascular blood‐contacting systems or extracardiovascular tissue‐only and blood‐handling architectures. Cross‐class comparison across shared semiquantitative criteria, including blood‐contact burden, biomimicry ...
Bergo Nicolò +7 more
wiley +1 more source
Author Correction: Artificial intelligence-enhanced diagnosis of degenerative joint disease using temporomandibular joint panoramic radiography and joint noise data. [PDF]
Sci RepChoi E +7 more
europepmc +1 more source
Efficacy and Safety of an Anti-nerve Growth Factor Antibody (Frunevetmab) for the Treatment of Degenerative Joint Disease-Associated Chronic Pain in Cats: A Multisite Pilot Field Study. [PDF]
Front Vet Sci, 2021 Gruen ME, Myers JAE, Lascelles BDX.
europepmc +1 more source
Severe Phenotype in an Indian Family With Progressive Pseudorheumatoid Arthropathy of Childhood
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Progressive pseudorheumatoid arthropathy of childhood (PPAC) is a rare autosomal recessive progressive condition that affects the cartilage of joints and bones. The symptoms of PPAC include stiffness of the joints, bony swelling of the toes and fingers, short stature, kyphosis, and muscle weakness.
Narinder Singh +5 more
wiley +1 more source