Results 161 to 170 of about 6,731,159 (297)

Fuyuan Huoxue Decoction Promotes Lumbar Interbody Fusion in Rats: Role of Macrophage‐Driven Inflammation and the TLR9/NF‐κB Pathway

open access: yesAdvanced Science, EarlyView.
Fuyuan Huoxue decoction improves lumbar interbody fusion in rats while reducing inflammatory macrophage activity and supporting bone‐forming stem cells. Experiments implicate extracellular DNA and TLR9/NF‐κB signaling in early responses. These findings point to coordinated control of inflammation and osteogenesis as a potential route to stronger spinal
Hongwei Gao   +8 more
wiley   +1 more source

 Evaluation of vacuum phenomenon in dogs with coxofemoral degenerative joint disease using computed tomography. [PDF]

open access: yesBMC Vet Res, 2020
Kanthavichit K   +7 more
europepmc   +1 more source

Integrated Single‐Cell and Spatial Transcriptomics Reveal Convergence on a Senescence‐Associated B Cell–MIF Signaling Axis in Joint Aging and Osteoarthritis Progression

open access: yesAdvanced Science, EarlyView.
Single‐cell and spatial transcriptomics implicate senescent B cells and macrophage migration inhibitory factor (MIF) signaling in aging and osteoarthritic joints. An injectable hydrogel combining quercetin with siRNA targeting MIF attenuates cartilage degeneration in a mouse model of osteoarthritis.
Weida Li   +11 more
wiley   +1 more source

Production and characterization of rNGFSP: a recombinant fusion immunogen eliciting dual anti-NGF and anti-Substance P therapeutic antibodies for Degenerative Joint Disease. [PDF]

open access: yesBiotechnol Rep (Amst)
Varela V   +15 more
europepmc   +1 more source

A prehistoric presentation of osteoarthritis (degenerative joint disease) in the marine reptile Tylosaurus

open access: yes
The fossilized remains of Tylosaurus, a gigantic marine predator from the time of the dinosaurs, were uncovered in the Late Cretaceous of South Dakota. Gross pathology was noted on the right fore-paddle. Investigation found considerable osteophyte growth
Rempert, Trevor
core  

Targeting Mitochondrial Redox Signaling Promotes Neuroregeneration and Functional Recovery in a Multiple Sclerosis Model

open access: yesAdvanced Science, EarlyView.
Modulation of mitochondrial redox signaling by furapyrrodole activates CYB5R3 and suppresses Notch signaling, unlocking the regenerative potential of endogenous neural progenitor cells. This approach promotes neurogenesis, oligodendrogenesis, and remyelination, thereby improving neuronal function in a mouse model of multiple sclerosis and identifying ...
Yuki Narushima   +18 more
wiley   +1 more source

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