Results 161 to 170 of about 159,239 (309)

Associations between early neutering, obesity, outdoor access, trauma and feline degenerative joint disease. [PDF]

J Feline Med Surg, 2021
Maniaki E, Murrell J, Langley-Hobbs SJ, Blackwell EJ.   +3 more
europepmc   +1 more source

Complementary multi‐omics profiling of chronic thromboembolic pulmonary hypertension reveals immune cell alterations, epigenetic changes, and genetically supported candidate genes

Animal Models and Experimental Medicine, EarlyView.
This study presents an integrative multi‐omics framework to uncover the molecular mechanisms and potential biomarkers of chronic thromboembolic pulmonary hypertension (CTEPH). Anthropometric and biochemical data were correlated using canonical correlation analysis, revealing key cardiometabolic associations. Single‐cell RNA sequencing identified immune
Xiaopeng Liu, Xia Zheng, Yajun Zhang, Yinghui Fang, Yanan Zhen   +4 more
wiley   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Investigating the 7-year cost-effectiveness of single-level cervical disc replacement compared to anterior cervical discectomy and fusion [PDF]

, 2017
Brochin, Robert L, Kim, Jun S, McAnany, Steven J, Merrill, Robert K, Overley, Samuel C, Qureshi, Sheeraz A   +5 more
core   +2 more sources

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

 Evaluation of vacuum phenomenon in dogs with coxofemoral degenerative joint disease using computed tomography. [PDF]

BMC Vet Res, 2020
Kanthavichit K, Klaengkaew A, Srisowanna N, Chaivoravitsakul N, Horoongruang K, Thanaboonnipat C, Soontornvipart K, Choisunirachon N.   +7 more
europepmc   +1 more source

Robenacoxib shows efficacy for the treatment of chronic degenerative joint disease-associated pain in cats: a randomized and blinded pilot clinical trial. [PDF]

Sci Rep, 2021
Adrian D, King JN, Parrish RS, King SB, C Budsberg S, Gruen ME, Lascelles BDX.   +6 more
europepmc   +1 more source

Diagnostic Value of Panoramic Radiographs in the Assessment of Degenerative Joint Disease: A Retrospective Study. [PDF]

Int Dent J
Maita I, Dhillon A, Friesen R, Almeida FT.   +3 more
europepmc   +1 more source

Evaluation of a nutritional supplement for the alleviation of pain associated with feline degenerative joint disease: a prospective, randomized, stratified, double-blind, placebo-controlled clinical trial. [PDF]

J Feline Med Surg, 2022
Cunningham R, Gruen ME, Thomson A, Lascelles BDX.   +3 more
europepmc   +1 more source