Results 141 to 150 of about 6,731,159 (297)

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

Degenerative joint disease induced by repeated intra-articular injections of monosodium urate crystals in rats as investigated by translational imaging. [PDF]

Sci Rep, 2022
Accart N, Dawson J, Obrecht M, Lambert C, Flueckiger M, Kreider J, Hatakeyama S, Richards PJ, Beckmann N.   +8 more
europepmc   +1 more source

Update on the pathophysiology of degenerative disc disease and new developments in treatment strategies

, 2010
Adam H Hsieh1,2 , S Tim Yoon31Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA; 2Department of Orthopedics, University of Maryland, Baltimore, MD, USA; 3Department of Orthopedic Surgery, Emory University, Chief of ...
S Tim Yoon, Adam H Hsieh
core  

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

Advanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu, Xi Li, Wenxuan He, Fenglin Li, Qican Ou, Yao Liu, Jiang Lei, Yanzi Bao, Huaxin Huang, Wei Feng, Yuanguang Tang, Xiaohui Qiu, Lu Gan, Yuefei Shen, Jin Wang, Yousheng Xiao   +15 more
wiley   +1 more source

Indicators of Health-Related Quality of Life in Cats With Degenerative Joint Disease: Systematic Review and Proposal of a Conceptual Framework. [PDF]

Front Vet Sci, 2021
Yeowell G, Burns D, Fatoye F, Gebrye T, Wright A, Mwacalimba K, Odeyemi I.   +6 more
europepmc   +1 more source

PERANAN SEKUEN AXIAL T2WI DAN SEKUEN AXIAL T2WI FAT SATURATION PADA PEMERIKSAAN MRI LUMBAL KASUS DEGENERATIVE SPINE DISEASE

, 2020
Degenerative spine disease merupakan patologi spinal column yang insidensinya meningkat karena peningkatan usia. Pemeriksaan MRI Lumbal menggunakan sekuen rutin Axial T2WI dapat mengidentifikasi perubahan pada facet joint. Fat saturation merupakan teknik
ISTIJABAH, Bagus Dwi Handoko, Nurdopo Baskoro, Rini Indrati   +3 more
core  

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Long-term supplementation with an undenatured type-II collagen (UC-II^®) formulation in dogs with degenerative joint disease: Exploratory study. [PDF]

Open Vet J, 2022
Cabezas MÁ, Benito J, Ortega Á, Garcia-Pedraza E.   +3 more
europepmc   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Articulating vs Static Spacers for Native Knee Infection in the Setting of Degenerative Joint Disease. [PDF]

Arthroplast Today, 2021
Hooper J, Arora P, Kappagoda S, Huddleston JI, Goodman SB, Amanatullah DF.   +5 more
europepmc   +1 more source