Results 21 to 30 of about 95,396 (158)

Identification of biomarkers and potential drug targets in DFU based on fundamental experiments and multi-omics joint analysis

Frontiers in Pharmacology
ObjectiveThis study aims to investigate the molecular mechanisms by which quercetin facilitates the treatment of diabetic foot ulcers (DFU).MethodsTranscriptome sequencing datasets for DFU, specifically GSE80178, GSE134431, and GSE147890, along with ...
Xudong Xin, Xudong Xin, Xudong Xin, Xudong Xin, Haidong Zhou, Song Huang, Wenzhao Zhang, Jiahou Xu, Wei Wang, Jihua Wei, Jihua Wei, Jihua Wei, Jihua Wei, Liqing Li   +13 more
doaj   +1 more source

Postoperative efficacy of chondroprotectors and diacerein in dogs with osteoarthritis secondary to cranial cruciate ligament disease

Open Veterinary Journal, 2023
Background: Cranial cruciate ligament disease is one of the leading causes of pelvic limb claudication in canines and osteoarthritis in the stifle joint. Historically, studies have focused on surgical options to improve the stability of the stifle joint,
Florencia Sollier Podesta, Daniela Fabiena Izquierdo Caquías   +1 more
doaj   +1 more source

Alpinia officinarum Hance: a comprehensive review of traditional uses, phytochemistry, pharmacokinetic and pharmacology

Frontiers in Pharmacology
The dried root and rhizome of Alpinia officinarum Hance (A. officinarum) have been widely used in traditional Chinese medicine for thousands of years to alleviate pain, promote digestion, warm the stomach, and disperse cold.
Xia Lei, Jiapeng Wang, Jiapeng Wang, Kun Zuo, Tianli Xia, Jinfeng Zhang, Xiangyue Xu, Qing Liu, Xiaoliang Li   +8 more
doaj   +1 more source

Criterion Validation Testing of Clinical Metrology Instruments for Measuring Degenerative Joint Disease Associated Mobility Impairment in Cats. [PDF]

PLoS ONE, 2015
Degenerative joint disease and associated pain are common in cats, particularly in older cats. There is a need for treatment options, however evaluation of putative therapies is limited by a lack of suitable, validated outcome measures that can be used ...
Margaret E Gruen, Emily H Griffith, Andrea E Thomson, Wendy Simpson, B Duncan X Lascelles   +4 more
doaj   +1 more source

RPL35 downregulated by mechanical overloading promotes chondrocyte senescence and osteoarthritis development via Hedgehog-Gli1 signaling

Journal of Orthopaedic Translation
Objectives: To investigate the potential role of Ribosomal protein L35 (RPL35) in regulating chondrocyte catabolic metabolism and to examine whether osteoarthritis (OA) progression can be delayed by overexpressing RPL35 in a mouse compression loading ...
Jinjian Zhu, Liangliang Liu, Rengui Lin, Xiongtian Guo, Jianbin Yin, Haoyu Xie, Yuheng Lu, Zhicheng Zhang, Hongbo Zhang, Zihao Yao, Haiyan Zhang, Xiangjiang Wang, Chun Zeng, Daozhang Cai   +13 more
doaj   +1 more source

Diacerein: A New Disease Modulating Agent in Osteoarthritis [PDF]

Indian Journal of Physical Medicine & Rehabilitation, 2007
Diacerein is a new anti-inflammatory analgesics and antipyretic drug, developed specially for the treatmentof osteoarthritis which is one of the most prevalent degenerative joint disease.
Medhi B, Singh PK, Prakash A, Sen R, Wadhwa S   +4 more
doaj  

Viscosupplementation in prevention and treatment of the degenerative joint disease

Studia Medyczne, 2016
Osteoarthritis (OA) is one of the most common musculoskeletal disorders. It limits patients’ functionality and life satisfaction significantly. Although there are numerous types of therapy, the success rate of conservative treatment is limited, and it is
Andrzej Kotela, Sylwia Sarzyńska, Maria Woźniak, Paweł Łęgosz, Małgorzata Starczyńska, Ireneusz Kotela   +5 more
doaj   +1 more source

Facet Joint Orientation and Tropism in Lumbar Degenerative Disc Disease and Spondylolisthesis

Global Spine Journal, 2014
Introduction Back pain is one of the most common reported health problems in elderly. Two common causes of back pain were included in this study, degenerative disc disease (DDD) and spondylolisthesis (DS). Since facet joint is one of many structures that
P. Chotiyarnwong, W. Pichaisak
doaj   +1 more source

Anatomical Features of the Sacroiliac Joint and Machine Learning-Based Classification of Disease Types

Diagnostics
Background and Objectives: Understanding the structural differences in the sacroiliac joint (SIJ) is essential for distinguishing inflammatory from degenerative disorders.
Rabia Koca, Fatih Ateş, Yavuz Bahadır Koca, Zeliha Fazlıoğulları, Mehmet Sedat Durmaz   +4 more
doaj   +1 more source

Thumb Arthrodesis in The Arthritis Cases: A Scoping Review

Journal Orthopaedi and Traumatology Surabaya
Backgrounds: Osteoarthritis in the thumb is a common condition affecting men and women, especially postmenopausal women, causing pain, swelling, and reduced hand function.
Ghifar Akbar, Viskasari Pintoko Kalanjati, Teddy Heri Wardhana   +2 more
doaj   +1 more source