Results 41 to 50 of about 12,592 (146)

Switching disease‐modifying therapies in patients with spinal muscular atrophy: A systematic review on effectiveness outcomes

British Journal of Clinical Pharmacology, EarlyView.
With multiple disease‐modifying therapies now available, treatment switching has become an important clinical consideration in the management of spinal muscular atrophy (SMA). While some switches are prompted by suboptimal clinical response, more commonly they are driven by treatment burden, convenience, or adverse events.
Andrej Belančić, Elvira Meni Maria Gkrinia, Patrick Eustaquio, Andrea Katrin Faour, Dinko Vitezić   +4 more
wiley   +1 more source

Posterior column osteotomy plus unilateral cage strutting for correction of lumbosacral fractional curve in degenerative lumbar scoliosis

Journal of Orthopaedic Surgery and Research, 2020
Background Inadequate release of the posterior spinal bone elements may hinder the correction of the lumbosacral fractional curve in degenerative lumbar scoliosis, since the lumbosacral junction tends to be particularly rigid and may already be fused ...
Hui Wang, Longjie Wang, Zhuoran Sun, Shuai Jiang, Weishi Li   +4 more
doaj   +1 more source

Cost‐utility analysis of nusinersen–risdiplam switch in patients with spinal muscular atrophy in Croatia: A discrete event simulation model

British Journal of Clinical Pharmacology, EarlyView.
Introduction In recent years, the treatment of spinal muscular atrophy (SMA), a rare disease, has significantly progressed, improving patients' survival and overall quality of life. However, current SMA treatments are expensive, and some (nusinersen) are very inconvenient for patients.
Andrej Belančić, Ivana Stević, Elvira Meni Maria Gkrinia, Dinko Vitezić, Slobodan Janković   +4 more
wiley   +1 more source

DEGENERATIVE SCOLIOSIS: A CASE REPORT

Journal Orthopaedi and Traumatology Surabaya, 2019
Background: Scoliosis in adults is a spinal deformity in adult patients with a Cobb angle of more than 10° in the coronal plane. Degenerative scoliosis is a term used for the presence of spinal coronal deviation in the elderly population due to segment ...
I Ketut Martiana, M Mukaddam Alaydrus
doaj   +1 more source

Adult spinal deformity and its relationship with height loss: a 34-year longitudinal cohort study

BMC Musculoskeletal Disorders, 2020
Background Age-related height loss is a normal physical change that occurs in all individuals over 50 years of age. Although many epidemiological studies on height loss have been conducted worldwide, none have been long-term longitudinal epidemiological ...
Mutsuya Shimizu, Tetsuya Kobayashi, Hisashi Chiba, Issei Senoo, Hiroshi Ito, Keisuke Matsukura, Senri Saito   +6 more
doaj   +1 more source

The Impact of Aging on the Anatomical Course of the Azygos Vein: A Retrospective, Computed Tomography Study

Clinical Anatomy, EarlyView.
ABSTRACT The azygos vein (AV) is typically described as ascending vertically to the right of the vertebral column before arching anteriorly to drain into the superior vena cava. However, a small number of studies suggest that it is found leftward in older adults.
Lauren R. Hector, Hania Paverd, Arthikkaa Thavakumar, Cecilia Brassett, Timothy J. Sadler   +4 more
wiley   +1 more source

Zebrafish inversin mutants develop scoliosis in the absence of laterality defects

Developmental Dynamics, EarlyView.
Abstract Background Human mutations in INVERSIN are associated with nephronophthisis, variable penetrance of situs inversus and congenital heart disease. Inversin has been shown to localize to cilia and many of the patient phenotypes are attributed to disrupted cilia function.
Christopher J. Derrick, Lorraine Eley, Deborah J. Henderson, Bill Chaudhry   +3 more
wiley   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source

Local foraminotomy for decompression as a factor of the spinal motion segment instability development in elderly patients with degenerative scoliosis

Хирургия позвоночника, 2019
Objective. To identify the risk of the spinal motion segment instability after local foraminotomy in elderly and senile patients with lumbar spinal stenosis associated with degenerative scoliosis. Material and Methods.
Dmitry A. Mikhailov, Dmitry A. Ptashnikov, Sergey V. Masevnin, Oleg A. Smekalenkov, Nikita S. Zaborowsky   +4 more
doaj   +1 more source

MDSGene Systematic Review of Common Forms of Dominant Hereditary Spastic Paraplegia: Novel Insights

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Hereditary spastic paraplegia (HSP) is a neurodegenerative disorder characterized by progressive spasticity and lower limb weakness. The most common forms of autosomal dominant HSP are caused by pathogenic variants in SPAST (SPG4 or HSP‐SPAST), ATL1 (SPG3A or HSP‐ATL1), and REEP1 (SPG31 or HSP‐REEP1).
Ce Kang, Rajasumi Rajalingam, Zachary Walls, Jana Huang, Christine Sun, Laura I. Rudaks, Dennis Yeow, Ashar Rasheed, Jenny W. Zhang, Moath Hamed, Marianthi Breza, Susen Schaake, Chetan Vekhande, Jason Massa, Robyn E. Massa, Aakash Shetty, Carolyn M. Sue, Franca Cambi, Oksana Suchowersky, Franca Vulinovic, Sonja Petkovic, Christine Klein, Katja Lohmann, Connie Marras, Kishore R. Kumar   +24 more
wiley   +1 more source