Using atomistic solution scattering modelling to elucidate the role of the Fc glycans in human IgG4.
PLoS ONEHuman immunoglobulin G (IgG) exists as four subclasses IgG1-4, each of which has two Fab subunits joined by two hinges to a Fc subunit. IgG4 has the shortest hinge with 12 residues.
Valentina A Spiteri +6 more
doaj +1 more source
Crystal structure of the glycosyltransferase SnogD from the biosynthetic pathway of nogalamycin in Streptomyces nogalater [PDF]
, 2014 The glycosyltransferase SnogD from Streptomyces nogalater transfers a nogalamine moiety to the metabolic intermediate 3′,4′-demethoxynogalose-1-hydroxynogalamycinone during the final steps of biosynthesis of the aromatic polyketide nogalamycin.
Claesson, Magnus +4 more
core +1 more source
Deglycosylation of wogonoside enhances its anticancer potential
Journal of Cancer Research and Therapeutics, 2018 Scutellaria baicalensis is commonly used in Asia as an herbal medicine to treat a variety of ailments, including cancer. Wogonoside, one major constituent of S. baicalensis, can be primarily converted to wogonin through deglycosylation via enteric microbiome metabolism.The antiproliferative effects of the glycoside (wogonoside) and its deglycosylated ...
Chong-Zhi, Wang +5 more
openaire +2 more sources
The development of a purification procedure for Peptide:n-Glycosidase A from Prunus amygdalus : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University [PDF]
, 1997 Peptide-N4-acetyl-β-glucosaminyl) asparagine amidases cleave the amide bond between N-linked glycans at N-acetylglucosamine and asparagine, liberating intact oligosaccharide chains from glycoproteins. Although PNGase A is commonly used by glycobiologists
Diepen, Angela Corinne van
core
Expression and purification of PNGase F( PNGase F) in escherichia coli and its functional study
上海师范大学学报. 自然科学版, 2013 N-glycosidase F(PNGase F)is a enzyme of deglycosylation,secreted by the gram-negative bacterium Flavobacterium meningosepticum.It’s theoretical molecular weight is about 34.8 kDa.In this study,the PNGase F gene of 945 bp was amplified by PCR technique.A ...
MIN Weiyong, LIU Li, ZHANG Zhou
doaj
Novel PNGase H+ from Amycolatopsis mediterranei: biochemical properties and food analysis potential
Food Materials ResearchPeptide-N4-(N-acetyl-β-D-glucosaminyl)asparagine amidases (PNGases) are essential biocatalysts for the deglycosylation of complex carbohydrates from glycoproteins, protein analysis and food quality assessment.
Bingqian Wei, Li Liu, Josef Voglmeir
doaj +1 more source
Protein deglycosylation can drastically affect the cellular uptake [PDF]
, 2019 Ghazaryan, A. +2 more
core +2 more sources
Current Issues in Molecular BiologyVitamin D3 transporter (DBP) is a multifunctional protein. Site-specific deglycosylation results in its conversion to group-specific component protein-derived macrophage activating factor (GcMAF), which is capable of activating macrophages.
Svetlana S. Kirikovich +15 more
doaj +1 more source
Carbohydrate masking of an antigenic epitope of influenza virus haemagglutinin independent of oligosaccharide size [PDF]
, 2017 Comparison of the haemagglutinins (HA) of the pathogenic avian influenza viruses A/FPV/Dutch/27 (H7N7) and A/FPV/Rostock/34 (H7N1) revealed 94.7% nucleotide and 93.8% amino acid sequence homologies.
Garten, Wolfgang +5 more
core