Results 91 to 100 of about 23,224 (220)

Targeted protein editing technique in living mammalian cells by peptide-fused PNGase

hLife
Various precise gene editing techniques at the DNA/RNA level, driven by clustered regularly interspaced short palindrome repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) technology, have gained significant prominence. Yet, research on targeted protein
Min Wu, Guijie Bai, Ziyi Zhang, Haixia Xiao, Wenliang Sun, Chaoguang Tian   +5 more
doaj   +1 more source

Crystallographic and physicochemical studies on anion-binding and deglycosylation of human lactoferrin : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in Chemistry at Massey University [PDF]

, 1995
Lactoferrin, a monomeric 80 kDa glycoprotein, is a major component of human milk and is found in many other exocrine secretions as well as in the neutrophilic granules of white blood cells.
Baker, Heather Mary
core  

Deglycosylation systematically improves N-glycoprotein identification in liquid chromatography-tandem mass spectrometry proteomics for analysis of cell wall stress responses in Saccharomyces cerevisiae lacking Alg3p [PDF]

, 2013
Post-translational modification of proteins with glycosylation is of key importance in many biological systems in eukaryotes, influencing fundamental biological processes and regulating protein function. Changes in glycosylation are therefore of interest
Adamczyk, Aebi, Bailey, Benjamin L. Schulz, Boorsma, Burda, Castillo, Comunale, Dall’Olio, Ecker, Helenius, Hennet, Huffaker, Izquiedro, Jaeken, Jensen, Jessani, Jung, Kapteyn, Kelleher, Kimura, Kolarich, Krokhin, Lizak, Lopez-Villar, Marth, Mohorko, Moukadiri, Mrsa, Nasab, Ohtsubo, Orlean, Ossola, Palmisano, Robinson, Rolli, Schulz, Schulz, Schulz, Schulz, Schulz, Selevsek, Sloane, Stahl-Zeng, Teparić, Tian, Ulla-Maja Bailey, Wilson, Yin, Yin, Zhang, Zhang   +51 more
core   +1 more source

Crystal structure of deglycosylated human IgG4-Fc

Molecular Immunology, 2014
The Fc region of IgG antibodies, important for effector functions such as antibody-dependent cell-mediated cytotoxicity, antibody-dependent cellular phagocytosis and complement activation, contains an oligosaccharide moiety covalently attached to each C(H)2 domain.
Davies, Anna M., Jefferis, Roy, Sutton, Brian J.   +2 more
openaire   +3 more sources

B4GALNT4‐Mediated Glycosylation of PDK1 Activates the PI3K‐AKT Signaling Pathway to Promote Prostate Cancer Progression

Advanced Science, Volume 13, Issue 23, 23 April 2026.
This study identifies B4GALNT4 as a key driver of prostate cancer (PCa). It shows that B4GALNT4 glycosylates PDK1 protein at the N531 site, which stabilizes the PDK1 and constitutively activates the PI3K‐AKT pathway. This mechanism promotes tumor cell proliferation, migration, and invasion. The findings establish the B4GALNT4‐PDK1 glycosylation axis as
Shaoqin Jiang, Mengqiang Li, Qingfu Su, Ruiling Dou, Shaoshan Lin, Jili Zhang, Xiaochen Sun, Haolan Yu, Wei Bao, Min Qu, Yan Wang, Chenghua Yang, Xu Gao   +12 more
wiley   +1 more source

Proof of the Mysterious Efficacy of Ginseng: Basic and Clinical Trials: Metabolic Activation of Ginsenoside: Deglycosylation by Intestinal Bacteria and Esterification With Fatty Acid

Journal of Pharmacological Sciences, 2004
Orally ingested ginsenoside passes through the stomach and small intestine without decomposition by either gastric juice or liver enzymes into the large intestine, where ginsenoside is deglycosylated by colonic bacteria followed by transit to the ...
Hideo Hasegawa
doaj   +1 more source

Brush border digestion : development of a physiologically relevant in vitro model : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Physiology at Massey University, Manawatū, New Zealand [PDF]

, 2018
Chapter Two has, in part, been published in the Springer publication, Reviews of Physiology, Biochemistry and Pharmacology, but the Author retains the right to publish the material in any collection consisting of the Author's own works: Hooton, D ...
Hooton, Diane Frances
core  

A Case Study and Review of the Literature on IgA Nephropathy in Crohn's Disease

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT IgA nephropathy (IgAN) is the most frequently reported glomerular disease associated with inflammatory bowel disease (IBD), particularly Crohn's disease (CD), although pediatric cases remain rare. We report IgAN in a 16‐year‐old male with CD following intestinal surgery and during long‐term infliximab therapy, with renal impairment occurring ...
Giovanna Fernanda Vazzana, Alessia Romano, Chiara Casuscelli, Alberto La Spada, Domenico Santoro, Roberto Chimenz, Claudio Romano   +6 more
wiley   +1 more source

Editorial: Inherited Protein Glycosylation Defects in Humans

Frontiers in Genetics, 2022
Aleksandra Jezela-Stanek, Karolina M. Stepien, Anna Tylki-Szymanska   +2 more
doaj   +1 more source

The role of epithelial cell adhesion molecule N-glycosylation on apoptosis in breast cancer cells

Tumor Biology, 2017
Glycosylation of cell surface proteins plays an important role in the regulation of apoptosis. It has been demonstrated that knockdown of epithelial cell adhesion molecule promoted apoptosis, inhibited cell proliferation, and caused cell-cycle arrest. In
Dandan Zhang, Xue Liu, Jiujiao Gao, Yan Sun, Tingjiao Liu, Qiu Yan, Xuesong Yang   +6 more
doaj   +1 more source