Results 81 to 90 of about 17,182 (211)

Strategy for modular assembly of tetravalent, multispecific antibodies

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Multispecific, multivalent antibodies (Abs) are a burgeoning class of drugs that dramatically expand the pharmacological repertoire beyond traditional therapeutic Abs. Here, we present a simple, modular approach to developing multispecific, multivalent Abs based on a Fab‐phage library with a single light chain.
Evan Mallette, Levi L. Blazer, Craig A. Hokanson, Chao Chen, Julia Garcia Perez, Alevtina Pavlenco, Lynda Ploder, Alexander U. Singer, Michael D. L. Suits, Sunil Bhakta, Jagath R. Junutula, Jarrett J. Adams, Sachdev S. Sidhu   +12 more
wiley   +1 more source

A Drosophila metallophosphoesterase mediates deglycosylation of rhodopsin

, 2016
Oligosaccharide chains of newly synthesized membrane receptors are trimmed and modified to optimize their trafficking and/or signalling before delivery to the cell surface. For most membrane receptors, the functional significance of oligosaccharide chain
Cao, Jinguo, Reddig, Keith, Han, Junhai, Xia, Wenjing, Xie, Wei, Li, Hong-Sheng, Hu, Wen, Li, Yi   +7 more
core   +1 more source

Targeted protein editing technique in living mammalian cells by peptide-fused PNGase

hLife
Various precise gene editing techniques at the DNA/RNA level, driven by clustered regularly interspaced short palindrome repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) technology, have gained significant prominence. Yet, research on targeted protein
Min Wu, Guijie Bai, Ziyi Zhang, Haixia Xiao, Wenliang Sun, Chaoguang Tian   +5 more
doaj   +1 more source

Real-Time Analysis on Drug-Antibody Ratio of Antibody-Drug Conjugates for Synthesis, Process Optimization, and Quality Control

Scientific Reports, 2017
Drug-antibody ratio (DAR) of antibody-drug conjugates (ADCs) is important for their therapeutic efficacy and pharmacokinetics, therefore control on DAR in synthesis process is a key for ADC quality control.
Yubo Tang, Feng Tang, Yang Yang, Lei Zhao, Hu Zhou, Jinhua Dong, Wei Huang   +6 more
doaj   +1 more source

Ginsenosides Rb1 and Rg1 Suppress Lipopolysaccharide‐Induced Inflammatory Gene Expression in Microglia and Astrocytes, Unlike Rb2

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Neuroinflammation, mediated by activated microglia and astrocytes, contributes to the progression of neurodegenerative diseases. Ginsenosides derived from Panax ginseng possess anti‐inflammatory properties. However, the comparative efficacy of structurally distinct ginsenosides and their activity across multiple glial cell types remains ...
Hanwoong Woo, Jeong‐im Choi, Sohee Kim, Jung Ki Min, Eunbi Lim, Sehyun Chae, Jieun Kim   +6 more
wiley   +1 more source

The Impact of Steroidal Glycoalkaloids on the Physiology of Phytophthora infestans, the Causative Agent of Potato Late Blight

Molecular Plant-Microbe Interactions, 2017
Steroidal glycoalkaloids (SGAs) are plant secondary metabolites known to be toxic to animals and humans and that have putative roles in defense against pests.
Paul Dahlin, Marion C. Müller, Sophia Ekengren, Lauren S. McKee, Vincent Bulone   +4 more
doaj   +1 more source

Evasins: Biology and Therapeutic Potential of Broad‐Spectrum Chemokine Inhibitors

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
ABSTRACT Ticks are haematophagous parasites that rely on uninterrupted bloodmeals for survival and need an effective strategy to suppress the host inflammatory response. Leukocyte recruitment is a chemokine‐mediated hallmark of inflammation, which ticks counteract via anti‐chemokine proteins in their saliva named evasins.
Emilia L. Bialek, Roos Buds, Ingrid Dijkgraaf, Pedro E. Marques   +3 more
wiley   +1 more source

Vaccination With Trichuris muris Poly‐Cysteine and Histidine‐Tailed Protein p43 Protects Against Chronic Infection

Parasite Immunology, Volume 48, Issue 10, October 2026.
ABSTRACT Trichuris trichiura is one of the soil transmitted geohelminths which together currently affect approximately 25% of the global population resulting in considerable morbidity particularly in children and young adults. Recent estimates put infection by T. trichiura at approximately 513 million.
Allison J. Bancroft, Kelly S. Hayes, Laura Campbell, Seona Thompson, Christina Dold, Luke Blackwell, Christine S. Rollier, David J. Thornton, Richard K. Grencis   +8 more
wiley   +1 more source

Editorial: Inherited Protein Glycosylation Defects in Humans

Frontiers in Genetics, 2022
Aleksandra Jezela-Stanek, Karolina M. Stepien, Anna Tylki-Szymanska   +2 more
doaj   +1 more source

PNGase Sensitivity Assay to Study the Folding Status of Proteins

Bio-Protocol, 2016
This protocol aims to evaluate folding status of proteins, utilizing peptide:N-glycanase (PNGase) sensitivity. In the cytosol, PNGase works as a deglycosylation-enzyme.
Satoshi Ninagawa, Kazutoshi Mori
doaj   +1 more source