Results 11 to 20 of about 2,207 (172)

Impact of software tools and kinetic model selection on myocardial blood flow and flow reserve quantitation in ¹³N-ammonia PET. [PDF]

J Appl Clin Med Phys
Abstract Background Quantitative assessment of myocardial perfusion using 13N‐ammonia PET with compartmental modeling enables evaluation of myocardial flow reserve (MFR) and prediction of patient prognosis. However, the reliability of these assessments can depend on the analytical methods used for quantitation.
Akiya N, Miwa K, Ando A, Miyaji N, Yamao T, Wachi K, Masubuchi M, Kimura S, Ito R, Komatsu A, Horikawa T, Fukushima K, Okizaki A, Miura S.   +13 more
europepmc   +2 more sources

A De Novo Designed Metalloprotein Displays Variable Thermal Stability and Binding Stoichiometry with Transition Metal Ions. [PDF]

Chembiochem
A de novo designed single‐chain coiled coil protein is unfolded in apo‐state but folds up upon addition of divalent transition metal ions Co(II), Ni(II), Cu(II), and Zn(II). The resulting metal‐bound complexes exhibit distinct thermal stability and metal stoichiometry, making this protein a promising starting point for the design of fully metal ...
Rooijakkers B, Verhagen G, Cramer-Blok A, Zuidinga E, Boyle AL.   +4 more
europepmc   +2 more sources

From Prebiotic Catalysts to Modern Applications: How Early Catalysts Inspire Today's Innovations

Israel Journal of Chemistry, Volume 66, Issue 4, July 2026.
Simple catalytic systems that may have operated under prebiotic conditions offer useful molecular principles for the design of modern functional materials. By examining how amino acids, peptide assemblies, and metal complexes achieve catalysis through simple chemical features, this review highlights how prebiotic chemistry can inspire new strategies ...
Omer Agazani, Meital Reches
wiley   +1 more source

CRISPR/Cas9‐based white pupae mutant lines in Bactrocera spp. for sterile insect technique applications

Insect Science, Volume 33, Issue 2, Page 463-475, April 2026.
Bactrocera fruit flies are significant horticultural pests that cause major economic losses. A “neoclassical approach” incorporating genome editing via CRISPR/Cas9 to develop genetic sexing strains (GSS) could render the sterile insect technique (SIT) against these pests more efficient and cost‐effective.
Chrysanthi Ioannidou, Maria‐Eleni Gregoriou, Marc F. Schetelig, Elena Drosopoulou, Kostas D. Mathiopoulos, Kostas Bourtzis   +5 more
wiley   +1 more source

Embracing Complexity: Peptides as Tunable Scaffolds in the Construction of Discrete Supramolecular Systems

Angewandte Chemie, Volume 137, Issue 34, August 18, 2025.
The inherent chirality, tunability, biocompatibility, and robustness of peptides provide an exciting opportunity for supramolecular chemistry. In this mini‐review, we explore uses of peptides in discrete supramolecular systems, how chemists can draw inspiration from larger biological assemblies, and discuss how embracing the complexity of peptide ...
Ben E. Barber, Ellen M. G. Jamieson, Leah E. M. White, Charlie T. McTernan   +3 more
wiley   +2 more sources

Synthesis, Bioactivity and Molecular Modeling Studies on Benzimidazole Derivatives and Its Isosteres as Potent AChE/BChE and GSK3β Inhibitors for Alzheimer's Disease

Chemical Biology &Drug Design, Volume 107, Issue 4, April 2026.
Compounds 1j, 1l, 2b, 2j, 3g, and 3l were found to have potent anti‐Alzheimer agents for AChE, BChE inhibitions, neuroprotective effects in the presence of H2O2 and GSK3β inhibitions. ABSTRACT A series of benzimidazoles and its analogs (benzoxazoles and benzothiazoles) bearing a benzohydrazide‐hydrazones moiety at the 2‐position were designed and ...
Gözde Sayar, Sulunay Parlar, Ayse Hande Tarikogullari, Mumin Alper Erdoğan, Guliz Armagan, Vildan Alptuzun   +5 more
wiley   +1 more source

Una resistenza “verde” contro il degrado urbano: il Guerrilla Gardening

Ri-vista: Ricerche per la Progettazione del Paesaggio, 2015
In the early 1970’s, a small group of American ambientalists squatted a vacant lot in Manhattan to create a small garden in response to the scarcity of public space in their neighbourhood.
Francesco Berni
doaj   +1 more source

Chemical Methods for Peptide and Protein Backbone Cleavage

ChemistryEurope, Volume 4, Issue 2, February 2026.
Protein cleavage plays essential roles in biology and is powerful for protein manipulation and functionalization as well as in recombinant expression and purification. Here, the historical background and most recent examples of chemical methods for protein and peptide backbone cleavage are discussed (part of the figure was generated in BioRender).
Miguel Angel Alena‐Rodriguez, Christian A. Olsen   +1 more
wiley   +1 more source

Evaluating zero‐shot prediction of monomeric protein design success by AlphaFold, ESMFold, and ProteinMPNN

Protein Science, Volume 35, Issue 2, February 2026.
Abstract De novo protein design has enabled the creation of proteins with diverse functionalities that are not found in nature. Despite recent advances, experimental success rates remain inconsistent and context‐dependent, posing a bottleneck for broader applications of de novo design.
Mario Garcia, Sugyan M. Dixit, Gabriel J. Rocklin   +2 more
wiley   +1 more source

The soluble state of the HIV‐1 Vpu protein forms a complex with Ca2+‐calmodulin

Protein Science, Volume 35, Issue 2, February 2026.
Abstract The HIV‐1 Vpu membrane protein is crucial to the virus lifecycle. Our recent studies revealed soluble Vpu oligomers, prompting further investigation into their interactions with cellular proteins. Notably, Vpu may form a complex with calmodulin (CaM) due to its putative CaM‐binding motif; however, experimental proof of this association is ...
Olamide Ishola, Md Majharul Islam, Elaheh Hadadianpour, Peter P. Borbat, Adeyemi Ogunbowale, Juan C. R. Amador, Elka R. Georgieva   +6 more
wiley   +1 more source