La questione dei centri storici esiste ancora?
In_Bo, 2010 L’analisi dello stato attuale del centro storico di Bologna ci restituisce un’immagine legata spesso al degrado fisico-sociale, associata a usi estremi (ipercommercio, iperuniversità, iperconsumo) e a carenze nei trasporti pubblici.
Piero Orlandi
doaj +1 more source
Calmodulin in Complex with Proteins and Small Molecule Ligands: Operating with the Element of Surprise. Implications for Structure-Based Drug Design [PDF]
, 2009 Calmodulin plays a role in several life processes, its flexibility allows binding of a number of different ligands from small molecules to amphiphilic peptide helices and proteins. Through the diversity of its functions, it is quite difficult to find new
Keserű, György Miklós +2 more
core
Arte Pubblica e Periferia. Il caso del Quartiere Sant'Elia a Cagliari: un fallimento di successo
Medea, 2017 Negli anni Novanta del secolo scorso si riaccende il dibattito sul ruolo giocato dall’arte nei processi di riqualificazione degli spazi urbani. Il nuovo ‘paradigma’ dell’Arte Pubblica, che si basa sulla partecipazione e il coinvolgimento del ‘pubblico ...
Michela Buttu
doaj +1 more source
Mass balance approximation of unfolding boosts potential‐based protein stability predictions
Protein Science, Volume 34, Issue 5, May 2025.Abstract Predicting protein stability changes upon single‐point mutations is crucial in computational biology, with applications in drug design, enzyme engineering, and understanding disease mechanisms. While deep‐learning approaches have emerged, many remain inaccessible for routine use.
Ivan Rossi +5 more
wiley +1 more source
Choline phosphorylation and regulation of transcription of choline kinase α in hypoxia[S]
Journal of Lipid Research, 2012 Choline kinase catalyzes the phosphorylation of choline, the first step of phospholipid synthesis. Increased phosphorylation of choline is a hallmark characteristic of the malignant phenotype in a variety of neoplasms.
Aditya Bansal +2 more
doaj +1 more source
The Ca2+-dependent Binding of Calmodulin to an N-terminal Motif of the Heterotrimeric G Protein beta Subunit [PDF]
, 1997 Ca2+ ion concentration changes are critical events in signal transduction. The Ca2+-dependent interactions of calmodulin (CaM) with its target proteins play an essential role in a variety of cellular functions.
Liu, Mingyao +4 more
core
From duplication to fusion: Expanding Dayhoff's model of protein evolution
Protein Science, Volume 34, Issue 3, March 2025.Abstract Dayhoff's hypothesis suggests that complex proteins emerged from simpler peptides or domains, which duplicated and fused to create more complex proteins and novel functions. These processes expanded and diversified the protein repertoire within organisms.
Yusran Abdillah Muthahari +2 more
wiley +1 more source
Il degrado della risorsa suolo, quale futuro per l’agricoltura e per l’ambiente?
Italian Journal of Agronomy, 2011 Soil is a vital resource for sustaining life of the Earth. This resource has a low ability for regeneration, while it is subjected to increasing human pressure; it is therefore, in need of protection, as recognized by the UE in Europe and by the FAO at ...
Claudio Colombo +2 more
doaj +1 more source
Simple solvation potential for coarse-grained models of proteins [PDF]
, 2006 We formulate a simple solvation potential based on a coarsed-grain representation of amino acids with two spheres modeling the $C_\alpha$ atom and an effective side-chain centroid.
Bhattacharyay, A., Seno, F., Trovato, A.
core +1 more source
A functional helix shuffled variant of the B domain of Staphylococcus aureus
Protein Science, Volume 34, Issue 2, February 2025.Abstract The B domain of protein A is a biotechnologically important three‐helix bundle protein. It binds the Fc fragment of antibodies with helix 1/2 and the Fab region with helix 2/3. Here we designed a helix shuffled variant by changing the connectivity of the helices, in order to redesign the helix bundle, yielding altered helix–loop–helix ...
Hanna Bobolowski +4 more
wiley +1 more source