Results 111 to 120 of about 7,724 (236)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
, 2019 This Guidebook is designed to encourage unprecedented cooperation between four-year institutions and community colleges. The advice goes far beyond articulation to creating a culture of cooperation and inclusion. From the time of widespread establishment
Student Affairs and Enrollment Management
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
On the Dirichlet problem for the nonlinear wave equation in domains with corners points
, 1996 Using Mawhin’s coincidence topological degree arguments and fixed point theory for non-expansive mappings results, we discuss the solvability of the Dirichlet problem for the semilinear equation of the vibrating string uxx − uyy + f(x, y, u) = 0 in ...
Ben-Naoum, Abdou Kouider
core
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Indicator Selection for Life Prediction of Polyimide Enameled Wire for Aviation Generators and Method for Establishing Life Curve-Based on Bayesian Nonlinear Regression. [PDF]
Polymers (Basel)Wang Z, Liu Y, Li T, Zhu P, Niu G, Du H.
europepmc +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
The Influence of Fiber Tension and Filament Winding Patterns on the Strength of Thin-Walled Fiber-Reinforced Polymer Composite Tubes. [PDF]
Polymers (Basel)Paczkowska K +2 more
europepmc +1 more source