Results 91 to 100 of about 1,369,116 (259)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 1981 Contained within the 5th Edition (1978 to 1995) of the National Atlas of Canada is a map that shows the annual sum of normal degree-days above 5 C (an indicator of total heat available for plants in the growing season). Data for period 1941 to 1970.
openaire +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Degree day models to forecast the seasonal phenology of Drosophila suzukii in tart cherry orchards in the Midwest U.S. [PDF]
PLoS One, 2020 Kamiyama MT +3 more
europepmc +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Hedging irrigated maize crop yields using temperature derivatives in Malawi
HeliyonAgriculture production yield varies with weather changes. This causes farmers incur loses. For instance, extreme temperature leads to low maize yield. This study describes incomplete temperature weather derivatives in agriculture markets and applies risk
Prince Blackson Dennis Chirwa +1 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
, 1981 Contained within the 5th Edition (1978 to 1995) of the National Atlas of Canada is a map that shows the annual sum of heating degree days (an indicator of building heating needs). Data for period 1941 to 1970. Companion sheet to Frost-Free Period, Growing Degree-Days, Last Frost in Spring and First Frost in Autumn.
openaire +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
The role of environmental parameter (degree day) of snowmelt runoff simulation
Soil & Environment, 2011 The upper Indus basin comprises the high mountains covered with snow and glaciers. So the major portion of flowfrom Indus basin is due to snow and glacier melt runoff. The terrain is difficult to measure the hydrological andhydraulics data.
Ghulam Nabi*, Muhammad Latif, Habib-ur-Rehman and Aftab Hussain Azhar
doaj