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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source

EPIDEMIA DE PINTA-PRETA DA BATATA E COMPARAÇÃO DE MÉTODOS PARA DETERMINAR O INÍCIO DOS SINTOMAS DA DOENÇA NA CULTURA DE BATATA EM CAMPO POTATO EARLY BLIGHT EPIDEMICS AND COMPARISON OF METHODS TO DETERMINE ITS INITIAL SYMPTOMS IN A POTATO FIELD</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Revista Facultad Nacional de Agronomía Medellín</i>, 2007 </span><br><span class="r_content">Três experimentos foram montados entre os anos de 2000 e 2002, em condições de campo, de Viçosa, estado de Minas Gerais, com a finalidade de avaliar o efeito de epidemias de pinta-preta (Alternaria solani) na produção de batata (Solanum tuberosum) e ...</span><br><span class="r_sub"><i>Rodrigo Orlando Campo Arana<span id="ma_3" style="display:none">, Laércio Zambolim, Luiz Claudio Costa</span> <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_3')">+2 more</a></small></i></span><br><small><a href="https://doaj.org/article/9c7e88d27f0049abbfa96ebbc55f22b2" target="_blank" rel="nofollow" title="doaj.org/article/9c7e88d27f0049abbfa96ebbc55f22b2">doaj</a> </small> <br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/1878-0261.70256" target="_blank" rel="nofollow">Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Molecular Oncology, EarlyView.</i></span><br><span class="r_content">Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.</span><br><span class="r_sub"><i>Yuho Ebata<span id="ma_4" style="display:none">, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi</span> <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_4')">+10 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/1878-0261.70256?mi=2or9o2m&af=R&AllField=degree-day&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/1878-0261.70256?mi=2or9o2m&af=R&AllField=degree-day&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small> <div id="more_4" style="display:none"><a href="/sci_redir.php?doi=10.1002%2F1878-0261.70256" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/1878-0261.70256'); alert('Copied the doi');">copy doi</a> <small>(10.1002/1878-0261.70256)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_4')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/1878-0261.70260" target="_blank" rel="nofollow">DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Molecular Oncology, EarlyView.</i></span><br><span class="r_content">Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.</span><br><span class="r_sub"><i>Chao Chen<span id="ma_5" style="display:none">, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang</span> <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_5')">+14 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/1878-0261.70260?mi=2or9o2m&af=R&AllField=degree-day&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/1878-0261.70260?mi=2or9o2m&af=R&AllField=degree-day&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small> <div id="more_5" style="display:none"><a href="/sci_redir.php?doi=10.1002%2F1878-0261.70260" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/1878-0261.70260'); alert('Copied the doi');">copy doi</a> <small>(10.1002/1878-0261.70260)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_5')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/1878-0261.70266" target="_blank" rel="nofollow">Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Molecular Oncology, EarlyView.</i></span><br><span class="r_content">IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.</span><br><span class="r_sub"><i>Matthew O. Ellis<span id="ma_6" style="display:none">, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay</span> <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_6')">+3 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/1878-0261.70266?mi=2or9o2m&af=R&AllField=degree-day&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/1878-0261.70266?mi=2or9o2m&af=R&AllField=degree-day&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small> <div id="more_6" style="display:none"><a href="/sci_redir.php?doi=10.1002%2F1878-0261.70266" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/1878-0261.70266'); alert('Copied the doi');">copy doi</a> <small>(10.1002/1878-0261.70266)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_6')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.3390/atmos16101153" target="_blank" rel="nofollow">Evaluation and Projection of Degree-Days and Degree-Days Categories in Southeast Europe Using EURO-CORDEX</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Atmosphere</i></span><br><span class="r_content">The temperature-based indicators heating and cooling degree days, are frequently utilized to quantitatively link indoor energy demand and outdoor thermal conditions, especially in the context of climate change. We present a comprehensive study of the heating and cooling degree-days and the degree-days categories for the near past (1976–2005), and the ...</span><br><span class="r_sub"><i>Hristo Chervenkov, Kiril Slavov</i></span><br><small><a href="https://explore.openaire.eu/search/publication?pid=10.3390%2Fatmos16101153" target="_blank" rel="nofollow" title="openaire.eu/search/publication?pid=10.3390%2Fatmos16101153">openaire</a> </small> <div id="more_7" style="display:none"><a href="/sci_redir.php?doi=10.3390%2Fatmos16101153" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.3390/atmos16101153'); alert('Copied the doi');">copy doi</a> <small>(10.3390/atmos16101153)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_7')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/1878-0261.70268" target="_blank" rel="nofollow">USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Molecular Oncology, EarlyView.</i></span><br><span class="r_content">We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic </span><br><span class="r_sub"><i>Amelie S Schober<span id="ma_8" style="display:none">, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra</span> <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_8')">+16 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/1878-0261.70268?mi=2or9o2m&af=R&AllField=degree-day&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/1878-0261.70268?mi=2or9o2m&af=R&AllField=degree-day&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small> <div id="more_8" style="display:none"><a href="/sci_redir.php?doi=10.1002%2F1878-0261.70268" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/1878-0261.70268'); alert('Copied the doi');">copy doi</a> <small>(10.1002/1878-0261.70268)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_8')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/2211-5463.70161" target="_blank" rel="nofollow">Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>FEBS Open Bio, EarlyView.</i></span><br><span class="r_content">RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.</span><br><span class="r_sub"><i>Selçuk Yavuz<span id="ma_9" style="display:none">, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller</span> <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_9')">+6 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/2211-5463.70161?mi=2or9o2m&af=R&AllField=degree-day&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/2211-5463.70161?mi=2or9o2m&af=R&AllField=degree-day&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small> <div id="more_9" style="display:none"><a href="/sci_redir.php?doi=10.1002%2F2211-5463.70161" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/2211-5463.70161'); alert('Copied the doi');">copy doi</a> <small>(10.1002/2211-5463.70161)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_9')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://ojs.pphouse.org/index.php/IJBSM/article/view/1147" target="_blank" rel="nofollow">Effect of Host Plants on the Growth and Development of the Polyphagous Defoliator Cricula Trifenestrata Helfer (Lepidoptera: Saturniidae)</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>International Journal of Bio-Resource and Stress Management</i>, 2017 </span><br><span class="r_content"> The effect of four host plant species [Mango, Mangifera indica L., Cinnamon, Cinnamomum cassia, Cashew, Anacardium occidentale L., Som, Machilus bombycina King], on biology of the polyphagous defoliator Cricula trifenestrata Helfer (Lepidoptera ...</span><br><span class="r_sub"><i>S. K. Gharde, N. Chaudhuri</i></span><br><small><a href="https://doaj.org/article/9798a48e11f443bcab4656adc982345e" target="_blank" rel="nofollow" title="doaj.org/article/9798a48e11f443bcab4656adc982345e">doaj</a> </small> <br></div><div class="r"><div style="margin-bottom:2px;overflow:hidden"><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-13._climate_action/" class="suggestion"onclick="show_loader();"><b>13. climate action</b></a><br/><a href="/q-15._life_on_land/" class="suggestion"onclick="show_loader();"><b>15. life on land</b></a><br/><a href="/q-7._clean_energy/" class="suggestion"onclick="show_loader();"><b>7. clean energy</b></a><br/></div><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-temperature/" class="suggestion"onclick="show_loader();"><b>temperature</b></a><br/><a href="/q-development/" class="suggestion"onclick="show_loader();"><b>development</b></a><br/><a href="/q-degree_day/" class="suggestion"onclick="show_loader();"><b>degree day</b></a><br/></div><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-graus-dia/" class="suggestion"onclick="show_loader();"><b>graus-dia</b></a><br/><a href="/q-11._sustainability/" class="suggestion"onclick="show_loader();"><b>11. sustainability</b></a><br/><a href="/q-growing_degree_day/" class="suggestion"onclick="show_loader();"><b>growing degree day</b></a><br/></div></div></div><div class="pagenav"><a href="/q-degree-day/p-10/" rel="nofollow"><b>previous</b></a> <a href="/q-degree-day/p-9/" rel="nofollow">9</a> <a href="/q-degree-day/p-10/" rel="nofollow">10</a> <b>11</b> <a href="/q-degree-day/p-12/" rel="nofollow">12</a> <a href="/q-degree-day/p-13/" rel="nofollow">13</a> <a href="/q-degree-day/p-12/" id="next" rel="nofollow"><b>next</b></a> </div><br></div> </div> <script>document.getElementById('loadingGif').style.display='none';</script><div style="width: 100%; height: 40px; bottom: 0px; background-color: #f5f5f5;"><div style="padding-left: 15px; padding-top: 10px"> <a href="/" rel="nofollow">Home</a> - <a href="/page-about/" rel="nofollow">About</a> - <a href="/page-disclaimer/" rel="nofollow">Disclaimer</a> - <a href="/page-privacy/" rel="nofollow">Privacy</a> </div></div> <link rel="stylesheet" href="//ajax.googleapis.com/ajax/libs/jqueryui/1.11.4/themes/smoothness/jquery-ui.min.css"/> </body> </html>