Results 121 to 130 of about 7,058,514 (292)
John Day Notice of Adopted Amendment (2010-11-26)
, 2010 344 pp. Adopted 2010-11-26. Department of Land Conservation and Development Notice of Adopted AmendmentDLCD awarded the City of John Day a planning grant for an update to the City's Development code.
John Day
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Foreshadowing the Monarchy’s Dilemma:A Rhetorical Analysis of Judges 19
TheoRhēmaThe aim of this research is to analyze Judges 19 from a rhetorical perspective, applying the technique of chiastic-topographical structure. The analysis further contends that the toponyms serve a literary-theological function by foreshadowing the ...
Albert-Beniamin Cucu
doaj
The role of environmental parameter (degree day) of snowmelt runoff simulation
Soil & Environment, 2011 The upper Indus basin comprises the high mountains covered with snow and glaciers. So the major portion of flowfrom Indus basin is due to snow and glacier melt runoff. The terrain is difficult to measure the hydrological andhydraulics data.
Ghulam Nabi*, Muhammad Latif, Habib-ur-Rehman and Aftab Hussain Azhar
doaj
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
, 1981 Contained within the 5th Edition (1978 to 1995) of the National Atlas of Canada is a map that shows the annual sum of heating degree days (an indicator of building heating needs). Data for period 1941 to 1970. Companion sheet to Frost-Free Period, Growing Degree-Days, Last Frost in Spring and First Frost in Autumn.
openaire +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source