Results 51 to 60 of about 9,203,524 (310)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Interdecadal variability of degree-day factors on Vestari Hagafellsjökull (Langjökull, Iceland) and the importance of threshold air temperatures

Journal of Glaciology, 2016
The skill of degree-day glacier melt models is highly dependent on the choice of degree-day factor (DDF), which is often assumed to remain constant in time.
T. Matthews, R. Hodgkins
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Mass balance evolution of Martial Este Glacier, Tierra del Fuego (Argentina) for the period 1960–2099 [PDF]

, 2009
The Martial Este Glacier in southern Tierra del Fuego was studied in order to estimate the surface mass balance from 1960 until 2099. For this reason a degree-day model was calibrated.
C. Schneider, M. Buttstädt, M. Möller, R. Iturraspe   +3 more
core   +1 more source

Comparison of surface mass balance of ice sheets simulated by positive-degree-day method and energy balance approach

, 2016
. Glacial cycles of the late Quaternary are controlled by the asymmetrically varying mass balance of continental ice sheets in the Northern Hemisphere. Surface mass balance is governed by processes of ablation and accumulation. Here two ablation schemes,
E. Bauer, A. Ganopolski
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Estimating the characteristics of runoff inflow into Lake Gojal in ungauged, highly glacierized upper Hunza River Basin, Pakistan [PDF]

, 2013
Motivated by the potential flood outburst of Lake Gojal in the ungauged highly glacierized (27%) upper Hunza River Basin (HRB) in Pakistan that was dammed by a massive landslide on 4 January 2010, we attempt to analyze the characteristics of water inflow
Hagemann, S., Xu, J., Zhang, S., Zhao, Q.   +3 more
core   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

INSURING HEAT RELATED RISKS IN AGRICULTURE WITH DEGREE-DAY WEATHER DERIVATIVES [PDF]

This paper presents a model and framework for pricing degree-day weather derivatives when the weather variable is a non-traded asset. The paper compares the options prices from the recommended model and compares it to a typical insurance-type model.Risk ...
Turvey, Calum G.
core   +1 more source