Results 121 to 130 of about 175,681 (256)
On the degree of approximation by modified Szász operator
Journal of Numerical Analysis and Approximation Theory, 1988 Let \(L_ n(f,x) = ne^{-nx} \sum^\infty_0 \frac{(nx)^ k}{k!} \int^\infty_0 e^{-nt} \frac{(nt)^ k}{k!} f(t) dt\), where \(f\in L[0,\infty)\). In this note the following result is established. Theorem. Let \(f^{(r)}\in C_ B[0,\infty)\) and \(f\in B[0,\infty)\), \(r\geq1\).
openaire +3 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Oscillator-qubit generalized quantum signal processing: a case study of the uracil cation vibronic model. [PDF]
Chem SciHong J, Kim SH, Min SK, Huh J.
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DEGREE OF APPROXIMATION BY BOUNDED HARMONIC FUNCTIONS [PDF]
Proceedings of the National Academy of Sciences, 1960 openaire +3 more sources
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Community structure-regulation coupling reveals optimal information diffusion. [PDF]
Nat CommunChen X +7 more
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Tree-Packing Revisited: Faster Fully Dynamic Min-Cut and Arboricity. [PDF]
Algorithmicade Vos T, Christiansen A.
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source