Results 111 to 120 of about 2,145,411 (284)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

EDGE-pro: Estimated Degree of Gene Expression in Prokaryotic Genomes

Evolutionary Bioinformatics, 2013
Background The expression levels of bacterial genes can be measured directly using next-generation sequencing (NGS) methods, offering much greater sensitivity and accuracy than earlier, microarray-based methods. Most bioinformatics software for estimating levels of gene expression from NGS data has been designed for eukaryotic genomes, with algorithms ...
Tanja Magoc, Derrick Wood, Steven L. Salzberg'   +2 more
openaire   +4 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

ROI extraction in corona virus (COVID 19) CT images using intuitionistic fuzzy edge detection

Heliyon
Edge detection is a vital aspect of medical image processing, playing a key role in delineating borders and contours within images. This capability is instrumental for various applications, including segmentation, feature extraction, and diagnostic ...
Kumar S.N, Kannadhasan S, Sherin Zafar, H Ajay Kumar   +3 more
doaj   +1 more source

Degree-associated edge-reconstruction numbers of double-brooms

, 2016
An edge-deleted subgraph of a graph $G$ is an {\it edge-card}. A {\it decard} consists of an edge-card and the degree of the missing edge. The {\it degree-associated edge-reconstruction number} of a graph $G$, denoted $\dern(G)$, is the minimum number of decards that suffice to reconstruct $G$.
Ma, Meijie, Zhou, Tingting
openaire   +2 more sources

Mixed hypergraphs with bounded degree: edge-coloring of mixed multigraphs

Theoretical Computer Science, 2003
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Král’, Daniel, Kratochvíl, Jan, Voss, Heinz-Jürgen   +2 more
openaire   +2 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Parameterized Complexity of Two Edge Contraction Problems with Degree Constraints [PDF]

, 2013
Motivated by recent results of Mathieson and Szeider (J. Comput. Syst. Sci. 78(1): 179–191, 2012), we study two graph modification problems where the goal is to obtain a graph whose vertices satisfy certain degree constraints. The Regular Contraction problem takes as input a graph G and two integers d and k, and the task is to decide whether G can be ...
Belmonte, R., Golovach, P.A., Hof, van 't P., Paulusma, D.   +3 more
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source