Results 131 to 140 of about 174,868,130 (283)
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
On graphs with equal edge connectivity and minimum degree
Discrete Mathematics, 1979 AbstractThe note contains some conditions on a graph implying that the edge connectivity is equal to the minimum degree. One of these conditions is that if d1⩾d2⩾⋯⩾dn is the degree sequence then ∑ll−1(d1+dn−1)>In−1 for 1 ⩽ l⩽ min {n2−1, dn}.
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Partial Degree Bounded Edge Packing Problem [PDF]
, 2012 9 pages. Being reviewed in FAW 2012.
openaire +4 more sources
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Oral History Interview with Jack Edge
The National Museum of the Pacific War presents a monologue with Jack Edge. Edge joined the Navy in 1941. He served aboard the USS Pelias (AS-14). They were conducting submarine overhauls at the Submarine Base where the ship was berthed during the ...
Edge, Jack
core
Reducing the maximum degree of a graph by deleting edges
Australas. J Comb., 2019 We investigate the smallest number λe(G) of edges that can be removed from a non-empty graph G so that the resulting graph has a smaller maximum degree. We prove that if m is the number of edges, k is the maximum degree, and t is the number of vertices of degree k, then λe(G) ≤ m+(k−1)t /2k−1. We also show that λe(G) ≤ m k if G is a tree.
Borg, Peter, Fenech, Kurt
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