Results 71 to 80 of about 3,067,250 (321)
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
Minimum-Loop Realization of Degree Sequences
Journal of Research of the National Bureau of Standards, 1982 Given a finite sequence D of nonnegative integers, let M(D) denote its maximum element and S(D) its sum. It is known that D is realizable as a degree sequence by some graph if and only if S(D) is even, and by a loopless graph if and only if the even integer S(D) - 2M(D) ⩾ 0.
Goldman, A. J., Byrd, R. H.
openaire +2 more sources
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Geometric randomization of real networks with prescribed degree sequence
New Journal of Physics, 2019 We introduce a model for the randomization of complex networks with geometric structure. The geometric randomization (GR) model assumes a homogeneous distribution of the nodes in a hidden similarity space and uses rewirings of the links to find ...
Michele Starnini +2 more
doaj +1 more source
Functional conservation of sequence determinants at rapidly evolving regulatory regions across mammals. [PDF]
PLoS Computational Biology, 2018 Recent advances in epigenomics have made it possible to map genome-wide regulatory regions using empirical methods. Subsequent comparative epigenomic studies have revealed that regulatory regions diverge rapidly between genome of different species, and ...
Iksoo Huh +3 more
doaj +1 more source
Asymptotic in a class of network models with an increasing sub-Gamma degree sequence [PDF]
, 2021 Luo Jing +3 more
openalex +1 more source
Reduced criteria for degree sequences
Discrete Mathematics, 2013 For many types of graphs, criteria have been discovered that give necessary and sufficient conditions for an integer sequence to be the degree sequence of such a graph. These criteria tend to take the form of a set of inequalities, and in the case of the Erd s-Gallai criterion (for simple undirected graphs) and the Gale-Ryser criterion (for bipartite ...
openaire +2 more sources
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
Largest Laplacian Eigenvalue and Degree Sequences of Trees [PDF]
, 2008 We investigate the structure of trees that have greatest maximum eigenvalue among all trees with a given degree sequence. We show that in such an extremal tree the degree sequence is non-increasing with respect to an ordering of the vertices that is ...
Biyikoglu, Tuerker +2 more
core +1 more source