Results 71 to 80 of about 2,991,925 (319)

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

open access: yesFEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield   +3 more
wiley   +1 more source

Degree sequences of multigraphs

open access: yesAnnales Universitatis Scientiarum Budapestinensis de Rolando Eötvös Nominatae. Sectio computatorica, 2012
Let a, b and n be integers, n ≥ 1 and b ≥ a ≥ 0. Let an (a, b, n)-graph defined as a loopless graph G(a, b, n) on n vertices {V1,...,Vn}, in which Vi and Vj are connected with at least a and at most b (directed or undirected) edges. If G(a, b, n) is directed, then it is called (a, b, n)-digraph and if it is undirected, then it is called (a, b, n ...
openaire   +2 more sources

Efficient counting of degree sequences [PDF]

open access: yesDiscrete Mathematics, 2019
Novel dynamic programming algorithms to count the set $D(n)$ of zero-free degree sequences of length $n$, the set $D_c(n)$ of degree sequences of connected graphs on $n$ vertices and the set $D_b(n)$ of degree sequences of biconnected graphs on $n$ vertices exactly are presented.
openaire   +3 more sources

Towards random uniform sampling of bipartite graphs with given degree sequence [PDF]

open access: yes, 2012
In this paper we consider a simple Markov chain for bipartite graphs with given degree sequence on $n$ vertices. We show that the mixing time of this Markov chain is bounded above by a polynomial in $n$ in case of {\em semi-regular} degree sequence.
Erdös, Péter L.   +2 more
core   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

open access: yesFEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan   +2 more
wiley   +1 more source

Optimization over Degree Sequences [PDF]

open access: yesSIAM Journal on Discrete Mathematics, 2018
We introduce and study the problem of optimizing arbitrary functions over degree sequences of hypergraphs and multihypergraphs. We show that over multihypergraphs the problem can be solved in polynomial time. For hypergraphs, we show that deciding if a given sequence is the degree sequence of a 3-hypergraph is NP-complete, thereby solving a 30 year ...
Shmuel Onn   +3 more
openaire   +3 more sources

Finding Fullerene Patches in Polynomial Time

open access: yes, 2009
We consider the following question, motivated by the enumeration of fullerenes. A fullerene patch is a 2-connected plane graph G in which inner faces have length 5 or 6, non-boundary vertices have degree 3, and boundary vertices have degree 2 or 3.
Bonsma, Paul, Breuer, Felix
core   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

open access: yesFEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi   +5 more
wiley   +1 more source

Weighted hypersoft configuration model

open access: yesPhysical Review Research, 2020
Maximum entropy null models of networks come in different flavors that depend on the type of constraints under which entropy is maximized. If the constraints are on degree sequences or distributions, we are dealing with configuration models.
Ivan Voitalov   +4 more
doaj   +1 more source

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

open access: yesFEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

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