Results 71 to 80 of about 5,199,165 (252)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Synchronization in random networks with given expected degree sequences [PDF]

, 2008
Synchronization in random networks with given expected degree sequences is studied. We also investigate in details the synchronization in networks whose topology is described by classical random graphs, power-law random graphs and hybrid graphs when N ...
Kocarev, L., Checco, P., Biey, Mario
core  

A permutation method for network assembly.

PLoS ONE, 2020
We present a method for assembling directed networks given a prescribed bi-degree (in- and out-degree) sequence. This method utilises permutations of initial adjacency matrix assemblies that conform to the prescribed in-degree sequence, yet violate the ...
Shawn A Means, Christian Bläsche, Carlo R Laing   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Core degree distribution and collapse sequence of time-sliced networks.

Core degree distribution and collapse sequence of time-sliced networks.
Donghao Cui (11218603), Xin Lu (24821), Chaomin Ou (17827417)   +2 more
core   +1 more source

The Number of Subtrees of Trees with Given Degree Sequence

, 2012
This article investigates some properties of the number of subtrees of a tree with given degree sequence. These results are used to characterize trees with the given degree sequence that have the largest number of subtrees, which generalize the recent ...
Hua Wang, Gray, Daniel, Xiu‐Mei Zhang, Xiao‐Dong Zhang, Daniel Gray, Zhang, Xiao-Dong, Xiu-mei Zhang, Zhang, Xiu-Mei, Xiao-dong Zhang, Wang, Hua   +9 more
core   +1 more source

Cognitive control of sequential knowledge in 2-year-olds: evidence from an incidental sequence-learning and generation-task [PDF]

, 2007
Thirty-eight two-year-olds were trained under incidental instructions on a six element deterministic sequence of spatial locations. Following training, participants were informed of the presence of a sequence and asked to either reproduce or suppress the
Bremner, Andrew J.; id_orcid, Bremner, Andrew, Kotsoni, E., Mareschal, Denis, Johnson, M.H., Cleeremans, Axel, Mareschal, D., Destrebecqz, Arnaud, Bremner, Andrew J., Csibra, Gergely   +9 more
core   +1 more source