Results 81 to 90 of about 1,235 (182)

Antiproliferative Activities and SwissADME Predictions of Physicochemical Properties of Carbonyl Group‐Modified Rotenone Analogues

ChemistryOpen, Volume 13, Issue 1, January 2024.
Rotenone derivatives were synthesized through modifications of the carbonyl group and their antiproliferative activities were evaluated against various cancer cell lines (MCF‐7, A549, and HCT116). The physicochemical properties and drug‐likeness of the derivatives were evaluated using the SwissADME webtool.
Rajelle D. Hernandez, Frances Abygail F. Genio, Jannelle R. Casanova, Marlon T. Conato, Monissa C. Paderes   +4 more
wiley   +1 more source

A New Prenylated Flavanone from Derris trifoliata Lour.

Molecules, 2012
A new flavanone, 4′,5,7-trihydroxy-6,8-di-(2-hydroxy-3-methylbut-3-enyl)- flavanone, was isolated from the aerial parts of Derris trifoliate, together with eleven known compounds: rotenone, tephrosin, 12a-hydroxyrotenone, deguelin, 6a,12a-dehydro ...
Hao Yin, Si Zhang, Zhihui Xiao, Ximin Qiu, Cheng Jiang, Xiongming Luo, Weihong He, Shengzi Liu   +7 more
doaj   +1 more source

Molecular interaction studies of Deguelin and its derivatives with Cyclin D1 and Cyclin E in cancer cell signaling pathway: The computational approach

Scientific Reports, 2019
Deguelin is a major active ingredient and principal component in several plants and it is a potential molecule to target proteins of cancer cell signaling pathway.
K. Lokhande, Shuchi Nagar, K. Swamy
semanticscholar   +1 more source

Using LC and Hierarchical Cluster Analysis as Tools to Distinguish Timbó Collections into Two Deguelia Species: A Contribution to Chemotaxonomy

Molecules, 2016
The species Deguelia utilis and Deguelia rufescens var. urucu, popularly known as “timbó,” have been used for many years as rotenone sources in insecticide formulations.
Danielle da Costa, Consuelo e Silva, Aline Pinheiro, Débora Frommenwiler, Mara Arruda, Giselle Guilhon, Cláudio Alves, Alberto Arruda, Milton Da Silva   +8 more
doaj   +1 more source

Mitochondrial Complex I Inhibitor Deguelin induces metabolic reprogramming and sensitizes vemurafenib resistant BRAFV600E mutation bearing metastatic melanoma cells.

Molecular Carcinogenesis, 2019
Treatment with vemurafenib, a potent and selective inhibitor of mitogen‐activated protein kinase signaling downstream of the BRAFV600E oncogene, elicits dramatic clinical responses in patients with metastatic melanoma. Unfortunately, the clinical utility
Evan L. Carpenter, Sharmeen Chagani, Dylan Nelson, P. Cassidy, M. Laws, G. Ganguli-Indra, A. Indra   +6 more
semanticscholar   +1 more source

Resveratrol Inhibits the Epidermal Growth Factor-Induced Migration of Osteoblasts: the Suppression of SAPK/JNK and Akt

Cellular Physiology and Biochemistry, 2017
Background/Aims: Resveratrol is a polyphenol enriched in the skins of grapes and berries, that shows various beneficial effects for human health. In the present study, we investigated the mechanism behind the epidermal growth factor (EGF)-induced ...
Tetsu Kawabata, Haruhiko Tokuda, Kazuhiko Fujita, Shingo Kainuma, Go Sakai, Rie Matsushima-Nishiwaki, Osamu Kozawa, Takanobu Otsuka   +7 more
doaj   +1 more source

Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors.

European journal of medicinal chemistry, 2019
A series of novel B and C-rings truncated deguelin derivatives have been designed and synthesized in the present study as heat shock protein 90 (Hsp90) inhibitors. The synthesized compounds exhibited micromolar antiproliferative potency toward a panel of
Hong Yao, Feijie Xu, Guangyu Wang, Shaowen Xie, Wenlong Li, Hequan Yao, Cong Ma, Zheying Zhu, Jinyi Xu, Shengtao Xu   +9 more
semanticscholar   +1 more source

Deguelin inhibits non-small cell lung cancer via down-regulating Hexokinases II-mediated glycolysis

OncoTarget, 2017
Hexokinases II (HK2) is a hub in the regulation of cancer cell glycolysis. Here we reported deguelin, a natural compound which has been studied in various tumor types, has a profound anti-tumor effect on human non-small cell lung cancer (NSCLC) via ...
Wei Li, F. Gao, Xiaoqian Ma, Ruike Wang, Xin Dong, Wei Wang   +5 more
semanticscholar   +1 more source

Kajian Heat Shock Protein 90 (HSP90) dalam Pencarian Kandidat Penghambatnya melalui Ekplorasi Bahan Alam Indonesia

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy), 2019
Exploration on anticancer candidates on inhibition of Heat Shock Protein (HSP) activity are increasing in the past ten years. Some of HSP90 inhibitor candidates were in third phase of clinical trials.
Rehmadanta Sitepu
doaj   +1 more source

Extracts from Field Margin Weeds Provide Economically Viable and Environmentally Benign Pest Control Compared to Synthetic Pesticides.

PLoS ONE, 2015
Plants with pesticidal properties have been investigated for decades as alternatives to synthetics, but most progress has been shown in the laboratory. Consequently, research on pesticidal plants is failing to address gaps in our knowledge that constrain
Prisila Mkenda, Regina Mwanauta, Philip C Stevenson, Patrick Ndakidemi, Kelvin Mtei, Steven R Belmain   +5 more
doaj   +1 more source