Results 71 to 80 of about 1,107 (189)
Química Nova, 2012 In the search for new larvicides from plants, we have investigated the potential activity of the rotenoids deguelin (1), 12a-hydroxy-α-toxicarol (2) and tephrosin (3), isolated from the bioactive ethanol extract of roots of Tephrosia toxicaria Pers ...
Jackson Nunes e Vasconcelos +10 more
doaj +1 more source
Thin Layer Densitometric Determination of Rotenone and Deguelin
Journal of AOAC INTERNATIONAL, 1969 Abstract Rutenone and deguelin are separated by chromatography on silver nitrate-impregnated silica gel G with chloroform acetone: acetic acid (196:3:1) solvent system. Glass plates, 20 × 20 cm, are coated with a special spreader producing a 0.25 mm layer and a 1.00 mm band at the upper end.
William H Tallent, Norman E Delfel
openaire +1 more source
A New Prenylated Flavanone from Derris trifoliata Lour.
Molecules, 2012 A new flavanone, 4′,5,7-trihydroxy-6,8-di-(2-hydroxy-3-methylbut-3-enyl)- flavanone, was isolated from the aerial parts of Derris trifoliate, together with eleven known compounds: rotenone, tephrosin, 12a-hydroxyrotenone, deguelin, 6a,12a-dehydro ...
Hao Yin +7 more
doaj +1 more source
Heat shock protein 90: biological functions, diseases, and therapeutic targets
MedComm, Volume 5, Issue 2, February 2024.Targeting the dynamic cycling of HSP90 and its interaction with co‐chaperones can promote protein maturation and client protein degradation, potentially offering effective antineoplastic strategies. Abstract Heat shock protein 90 (Hsp90) is a predominant member among Heat shock proteins (HSPs), playing a central role in cellular protection and ...
Huiyun Wei +7 more
wiley +1 more source
ChemistryOpen, Volume 13, Issue 1, January 2024.Rotenone derivatives were synthesized through modifications of the carbonyl group and their antiproliferative activities were evaluated against various cancer cell lines (MCF‐7, A549, and HCT116). The physicochemical properties and drug‐likeness of the derivatives were evaluated using the SwissADME webtool.
Rajelle D. Hernandez +4 more
wiley +1 more source
Docking of deguelin on anti-apoptotic proteins.
, 2016 (A) Structure of deguelin arrow indicates the binding of deguelin on Bcl-2 (B) The docking of deguelin on BH3 domain of hydrophobic group of anti-apoptotic protein Bcl-xl (C) Binding of deguelin on MCL-1 (D) Binding of deguelin molecule on ERK-1 near the
Ashraf Ali (625827) +15 more
core +1 more source
Molecules, 2016 The species Deguelia utilis and Deguelia rufescens var. urucu, popularly known as “timbó,” have been used for many years as rotenone sources in insecticide formulations.
Danielle da Costa +8 more
doaj +1 more source
Deguelin down-regulates survivin and Cdk4.
, 2013 Hep-2 cells were exposed to deguelin at indicated concentration (10, 25, 50 and 100 µM) for 24 hours, expression levels of survivin, Cdk4 and tubulin were measured by western blot (A).The association between survivin, Cdk4 and Hsp 90 as well as the ...
Chun-cheng Lu (276392) +6 more
core +1 more source
Cellular Physiology and Biochemistry, 2017 Background/Aims: Resveratrol is a polyphenol enriched in the skins of grapes and berries, that shows various beneficial effects for human health. In the present study, we investigated the mechanism behind the epidermal growth factor (EGF)-induced ...
Tetsu Kawabata +7 more
doaj +1 more source
STUDIES TOWARD TOTAL SYNTHESIS OF (-)-DEGUELIN
, 2013 Deguelin, as a rotenoid, has emerged as an attractive pharmacophore for chemprevention due to its effectiveness for both in vitro and in vivo models.
Li, Bao
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