EBioMedicine, 2017 Aurora B kinase has emerged as a key regulator of mitosis and deregulation of Aurora B activity is closely related to the development and progression of human cancers.
Xinfang Yu +5 more
doaj +2 more sources
Prediction of new C-terminal Hsp90 inhibitors based on deguelin scaffold: homology modeling, virtual screening, QM/MM docking, MM/GBSA, and molecular dynamics simulations [PDF]
Research in Pharmaceutical SciencesBackground and purpose: The N-terminal Hsp90 inhibitors are promising targets for cancer treatment; however, inducing the heat shock response is one of the most significant limitations.
Maryam Abbasi +2 more
doaj +2 more sources
Deguelin inhibits perineural invasion in esophageal squamous cell carcinoma via targeting BDNF/TrkB axis [PDF]
Cancer Biology & TherapyBackground Perineural invasion (PNI) represents a uniquely distinctive pathway for tumor metastasis, but its underlying molecular mechanisms and therapy remain unclear.Methods Bioinformatics analysis and transcriptomic sequencing were first employed to ...
Qiying Wei +7 more
doaj +2 more sources
Deguelin induces apoptosis in colorectal cancer cells by activating the p38 MAPK pathway
Cancer Management and Research, 2018 Liubo Chen,1,2,* Kai Jiang,1,2,* Haiyan Chen,1,3,* Yang Tang,1,2 Xinyi Zhou,1,2 Yinuo Tan,1,4 Ying Yuan,1,4 Qian Xiao,1,2 Kefeng Ding1,2 1Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key ...
Chen L +8 more
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Novel insights into immunopathogenesis and crucial biomarkers between primary open-angle glaucoma and systemic lupus erythematosus. [PDF]
IMetaOmicsThis study revealed a novel correlation between systemic lupus erythematosus (SLE) and primary open‐angle glaucoma (POAG) through comprehensive bioinformatics analysis and experimentation, identifying biomarkers and immunopathogenesis for future research and treatment of SLE‐related POAG.
Liu Y +5 more
europepmc +2 more sources
Deguelin inhibits the proliferation of human multiple myeloma cells by inducing apoptosis and G2/M cell cycle arrest: Involvement of Akt and p38 MAPK signalling pathway [PDF]
Acta PharmaceuticaDeguelin exhibits antiproliferative activity against various cancer cell types. Previous studies have reported that deguelin exhibits pro-apoptotic activity against human cancer cells. The current study aimed at further elaborating the anticancer effects
Sun Kening +4 more
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Intestinal deguelin drives resistance to acetaminophen-induced hepatotoxicity in female mice [PDF]
Gut MicrobesAcetaminophen (APAP) overdose is a leading cause of drug-induced liver injury (DILI), with gender-specific differences in susceptibility. However, the mechanism underlying this phenomenon remains unclear.
Shenhai Gong +18 more
doaj +2 more sources
Deguelin targets multiple oncogenic signaling pathways to combat human malignancies
Pharmacological Research, 2021 Cancer is an anomalous growth and differentiation of cells known to be governed by oncogenic factors. Plant-based natural metabolites have been well recognized to possess chemopreventive properties.
Aggarwal, Vaishali +11 more
core +3 more sources
The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts
Viruses, 2018 Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus for which there is no vaccine or cure. This viral infection, once acquired, is life-long, residing latently in hematopoietic cells.
Eain A Murphy +2 more
exaly +3 more sources
Deguelin action involves c-Met and EGFR signaling pathways in triple negative breast cancer cells.
PLoS ONE, 2013 BackgroundTreatment of breast cancer patients with antiestrogens and aromatase inhibitor(s) or Herceptin have shown significant success in steroid receptor positive or Her-2+ breast cancers respectively.
Rajeshwari Mehta +7 more
doaj +2 more sources