Results 51 to 60 of about 1,107 (189)
Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer
Medicinal Research Reviews, EarlyView.ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek +3 more
wiley +1 more source
Deguelin down-regulates Akt signaling.
, 2013 Hep-2 cells were exposed to deguelin at indicated concentration (10, 25, 50 and 100 µM) for 24 hours, total- and phospho- levels of Akt as well as phosphorylation level of S6K were measured by Western blot using indicated antibodies (A).The association ...
Chun-cheng Lu (276392) +6 more
core +1 more source
Recent Advances in Carbonyl–Olefin and Carbonyl–Alkyne Metathesis Reactions
ChemistryEurope, Volume 4, Issue 4, April 2026.Carbonyl–olefin and carbonyl–alkyne metathesis enable atom‐economic C–C bond formation beyond classical olefin metathesis. This review highlights recent advances in photochemical, Lewis‐acid, Brønsted‐acid, and organocatalytic strategies, mechanistic insights, and synthetic applications, showcasing carbonyl metathesis as a versatile platform for modern
Komal Kalonia +2 more
wiley +1 more source
, 2018 A concise and protecting-group-free total synthesis of the antiproliferative natural product (±)-deguelin (2) was accomplished in four steps and 62% overall yield from commercially available precursors.
Shengtao Xu (513564) +6 more
core +1 more source
Ethnomedicinal Practices of the Fabaceae Family in Tanzania: A Systematic Review
The Scientific World Journal, Volume 2026, Issue 1, 2026.This study is aimed at reviewing the ethnomedicinal, phytochemical and pharmacological properties of Fabaceae species used as sources of traditional medications in Tanzania. Using the Systematic Reviews and Meta‐Analyses (PRISMA) methodology, a comprehensive review was conducted on Fabaceae species used by Tanzanians through electronic databases such ...
David Sylvester Kacholi, Kalyani Sen
wiley +1 more source
A Novel Derivative of the Natural Agent Deguelin for Cancer Chemoprevention and Therapy [PDF]
Cancer Prevention Research, 2008 Abstract The natural compound deguelin has promising preventive and therapeutic activity against diverse cancers by directly binding to heat shock protein-90 and thus suppressing its function. Potential side effects of deguelin over a certain dose, however, could be a substantial obstacle to its clinical use. To develop a derivative(s)
Woo-Young, Kim +14 more
openaire +2 more sources
Chemotherapeutic potential of deguelin and evaluation of new agents for skin cancer chemoprevention.
, 2003 Chemotherapeutic potential of deguelin and evaluation of new agents for skin cancer ...
Joell Janette. Gills (7986656)
core +4 more sources
Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro +5 more
wiley +1 more source
Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer
Oncology Reports, 2010 Gastric cancer is often diagnosed in locally advanced or metastatic stages, which preludes a poor prognosis. As only 10% of patients with advanced gastric cancer treated with chemotherapy survive 2 years, new approaches for preventing and controlling the disease are required. We therefore, assessed in gastric cancer cells the chemotherapeutic potential
Hyunseung, Lee +3 more
openaire +3 more sources
Potentiation of fludarabine action by deguelin.
, 2016 PBMCs from 2 CLL patients were treated with 10 μM deguelin, 1 μg/ml fludarabine or the combination of both, and co-cultured with 3T3-CD40L cell line up to 120h (same samples as in Fig 4B, 4C and 4D).
Silvia Rosado (39145) +9 more
core +1 more source