Deguelin inhibits perineural invasion in esophageal squamous cell carcinoma via targeting BDNF/TrkB axis [PDF]
Cancer Biology & TherapyBackground Perineural invasion (PNI) represents a uniquely distinctive pathway for tumor metastasis, but its underlying molecular mechanisms and therapy remain unclear.Methods Bioinformatics analysis and transcriptomic sequencing were first employed to ...
Qiying Wei +7 more
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Antiangiogenic effect of deguelin on choroidal neovascularization
The Journal of Pharmacology and Experimental Therapeutics, 2007 Age-related macular degeneration is the leading cause of blindness in the elderly. Choroidal neovascularization (CNV) leads to severe vision loss in patients of age-related macular degeneration.
Yu, Young Suk +6 more
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Akt inhibitor deguelin aggravates inflammation and fibrosis in myocarditis [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): Myocarditis is characterized by inflammatory cell infiltration in myocardial stroma. Attenuation of tumor necrosis factor (TNF)-α and interleukin (IL)-1β is a reliable mark for improving the prognosis.
Shanshan Li +10 more
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Molecules, 2014 Osteosarcoma is the most common malignant primary bone tumor in children and young adults and lung metastasis is the main cause of death in those patients. Deguelin, a naturally occurring rotenoid, is known to be an Akt inhibitor and to exhibit cytotoxic
Hung-Sheng Shang +2 more
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Efficacy of Deguelin and Silibinin on Benzo(a)pyrene-Induced Lung Tumorigenesis in A/J Mice [PDF]
Neoplasia: An International Journal for Oncology Research, 2005 We evaluated deguelin and silibinin in A/J mice treated with the tobacco-specific carcinogen benzo(a)pyrene (BP) for their ability to inhibit pulmonary adenoma formation and growth. Animals were treated with either deguelin (5.0 or 10.0 mg/kg body weight,
Ying Yan +4 more
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Deguelin induces apoptosis in colorectal cancer cells by activating the p38 MAPK pathway
Cancer Management and Research, 2018 Liubo Chen,1,2,* Kai Jiang,1,2,* Haiyan Chen,1,3,* Yang Tang,1,2 Xinyi Zhou,1,2 Yinuo Tan,1,4 Ying Yuan,1,4 Qian Xiao,1,2 Kefeng Ding1,2 1Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key ...
Chen L +8 more
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Deguelin targets multiple oncogenic signaling pathways to combat human malignancies
Pharmacological Research, 2021 Cancer is an anomalous growth and differentiation of cells known to be governed by oncogenic factors. Plant-based natural metabolites have been well recognized to possess chemopreventive properties.
Aggarwal, Vaishali +11 more
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The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts
Viruses, 2018 Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus for which there is no vaccine or cure. This viral infection, once acquired, is life-long, residing latently in hematopoietic cells.
Eain A Murphy +2 more
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Deguelin action involves c-Met and EGFR signaling pathways in triple negative breast cancer cells.
PLoS ONE, 2013 BackgroundTreatment of breast cancer patients with antiestrogens and aromatase inhibitor(s) or Herceptin have shown significant success in steroid receptor positive or Her-2+ breast cancers respectively.
Rajeshwari Mehta +7 more
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Deguelin inhibits the proliferation of human multiple myeloma cells by inducing apoptosis and G2/M cell cycle arrest: Involvement of Akt and p38 MAPK signalling pathway [PDF]
Acta PharmaceuticaDeguelin exhibits antiproliferative activity against various cancer cell types. Previous studies have reported that deguelin exhibits pro-apoptotic activity against human cancer cells. The current study aimed at further elaborating the anticancer effects
Sun Kening +4 more
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