Results 51 to 60 of about 6,549 (185)

GSK3α‐mediated regulation of the RNA demethylase fat mass and obesity‐associated protein (FTO) during murine spermatogenesis

The FEBS Journal, EarlyView.
FTO regulates mRNA stability and translational efficiency through its m6A‐demethylation activity. GSK3 functions as an upstream regulator of FTO, leading to its inhibition via phosphorylation. In male germ cells, FTO activity is kept in check by GSK3α.
Neha Choudhari, Budheswar Dehury, Rounak Roy, Radhakrishnan Periyasamy, Indrashis Bhattacharya, Mahesh Sahare, Srinivasan Vijayraghavan, Souvik Dey   +7 more
wiley   +1 more source

DEHP exposure destroys blood-testis barrier (BTB) integrity of immature testes through excessive ROS-mediated autophagy

Genes and Diseases, 2018
Di-(2-ethylhexyl) phthalate (DEHP), is known to impair testicular functions and reproduction. However, its effects on immature testis Blood-testis barrier (BTB) and the underlying mechanisms remain obscure.
W.E.I. Yi, Tang Xiang-Liang, Zhou Yu, Liu Bin, Shen Lian-Ju, Long Chun-lan, L.I.N. Tao, H.E. Da-wei, W.U. Sheng-de, W.E.I. Guang-hui   +9 more
doaj   +1 more source

Red blood cells stored in anticoagulant versus additive solution for large volume transfusions in pediatric patients undergoing cardiopulmonary bypass

Transfusion, EarlyView.
Abstract Background The safety of red blood cells (RBCs) in additive solutions (AS) for large‐volume transfusion (LVT) in pediatrics remains understudied. This study examines the laboratory and clinical impact of CPD‐stored products versus CP2D/AS‐3 products in pediatric patients receiving LVT during cardiac surgery.
Nabiha H. Saifee, Meghan Delaney
wiley   +1 more source

The Cytotoxic and genotoxic effects of di-isononyl phthalate and di-(2-ethylhexyl) phthalate: An in vitro and in vivo approach on toxicological assessment

Journal of BioScience and Biotechnology, 2019
The aim of the present study was to analyze the cytotoxic and genotoxic effects of two selected phthalates, di-isononyl phthalate (DINP) and di-(2-ethylhexyl) phthalate (DEHP) in vivo and in vitro using fish model, Oreochromis mossambicus and cell ...
Venugopal Revathy, Kumari C. Chitra
doaj  

Evaluation of the in vitro quality of X‐ray irradiated red cell concentrates processed and stored using di(2‐ethylhexyl) terephthalate plasticized blood bag sets

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Polyvinyl chloride (PVC) blood bags plasticized with di(2‐ethylhexyl) phthalate (DEHP) have long been the standard for red blood cell (RBC) storage. Due to safety concerns, alternatives like di(2‐ethylhexyl) terephthalate (DEHT), in combination with next‐generation additive solutions like phosphate‐adenine‐glucose ...
Carly Olafson, Sanaz Hemmatibardehshahi, Geraldine M. Walsh, Anita Howell   +3 more
wiley   +1 more source

Long-term di-(2-ethylhexyl) phthalate exposure reduces sorafenib treatment efficacy by enhancing mesenchymal transition in hepatocellular carcinoma

Ecotoxicology and Environmental Safety
Di(2-ethylhexyl) phthalate (DEHP) is a worldwide common plasticizer. Nevertheless, DEHP is easily leached out to the environment due to the lack of covalent bonds with plastic. High dose of DEHP exposure is often observed in hemodialysis patients because
Ming-Syuan Shih, Fat-Moon Suk, Wan-Chun Chiu, Chun-Ya Lee, Fang-Yu Hsu, Yi-Jen Liao   +5 more
doaj   +1 more source

Di(2‐Ethylhexyl) Phthalate Exposure and Risk of Diabetic Kidney Disease: Epidemiological Association and Mechanistic Insights

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Objective This study aims to explore the association between exposure to di‐(2‐ethylhexyl) phthalate (DEHP) and diabetic kidney disease (DKD), and to elucidate its potential molecular mechanisms. The study findings provide scientific evidence for the prevention and control of environmental risk factors related to DKD.
Dapeng Yin, Yan Li, Wei Wu, Xiaojuan Wang, Junhua He, Yikun Zhu, Jin Li   +6 more
wiley   +1 more source

Direct and transgenerational effects of low doses of perinatal di-(2-ethylhexyl) phthalate (DEHP) on social behaviors in mice. [PDF]

PLoS ONE, 2017
Di-(2-ethylhexyl) phthalate (DEHP) is an endocrine disrupting chemical commonly used as a plasticizer in medical equipment, food packaging, flooring, and children's toys.
Kayla M Quinnies, Erin P Harris, Rodney W Snyder, Susan S Sumner, Emilie F Rissman   +4 more
doaj   +1 more source

Mapping Steroidogenic Perturbations Under Endocrine Disruptor Mixtures Across Demographic Subgroups: Structural and Metabolomic Insights

Advanced Science, Volume 13, Issue 46, 17 August 2026.
Population‐scale EDC–hormone association mapping among 4255 participants across demographic subgroups identifies phthalate metabolites as the most consistent signals associated with lower testosterone‐related markers in males. Integrative mechanistic validation prioritizes MCPP as a key phthalate metabolite linked to CYP17A1‐centered disruption of ...
Yanling Chen, Lei Huang, Yingtong Jiang, Guohong Zhao, Mengyuan Zhu, Xiulian Lu, Lang Lang, Akinpelumi Oluwatobiloba Esther, Longhao Fan, Yuqi Jiang, Chang Sun, Xiaoling Zhang, Kun Zhou, Xiaoming Ji, Minjian Chen   +14 more
wiley   +1 more source

The effects of di(2-ethylhexyl) phthalate exposure in women with polycystic ovary syndrome undergoing fertilization

Journal of International Medical Research, 2019
Objectives Di(2-ethylhexyl) phthalate (DEHP) is a common endocrine-disrupting chemical, which has potential reproductive toxicity. This study aimed to explore the effects of DEHP exposure in women with polycystic ovary syndrome (PCOS) undergoing in vitro
Yue Jin, Qing Zhang, Jie-Xue Pan, Fang-Fang Wang, Fan Qu   +4 more
doaj   +1 more source