Results 31 to 40 of about 6,549 (185)

LXRα and PPARα Mediated Hepatic Lipid Metabolic Disruption Induced by the UV Filter EHMC in 2D and 3D HepaRG Cell Models

Food Safety and Health, EarlyView.
Dietary UV filter EHMC induces hepatic steatosis in HepaRG cells at noncytotoxic concentrations. Mechanistically, EHMC binds nuclear receptors (LXRα, PPARα), upregulating SREBP‐1 to accelerate fatty acid synthesis. These findings highlight the potential metabolic toxicity of widespread EHMC exposure through food sources.
Shanglin Yang, Na Li, Yingnan Han, Mei Ma   +3 more
wiley   +1 more source

Effect of Di(2-ethylhexyl)phthalate on Helicobacter pylori-Induced Apoptosis in AGS Cells

Gastroenterology Research and Practice, 2013
Plastic products are wildly used in human life. Di(2-ethylhexyl)phthalate (DEHP) is an essential additive in plastic manufacturing and is used as plasticizer for many products including plastic food packaging. DEHP is a teratogenic compound and can cause
Chuang-Hao Lin, Chien-Yi Wu, Hwang-Shang Kou, Chiao-Yun Chen, Meng-Chuan Huang, Huang-Ming Hu, Meng-Chieh Wu, Chien-Yu Lu, Deng-Chyang Wu, Ming-Tsang Wu, Fu-Chen Kuo   +10 more
doaj   +1 more source

Pilot study on novel blood containers with alternative plasticizers for red cell concentrate storage. [PDF]

PLoS ONE, 2017
Di (2-ethylhexyl) phthalate (DEHP), a typical plasticizer used for polyvinyl chloride (PVC) blood containers, is eluted from the blood containers and exerts protective effects on red blood cells.
Yuki Morishita, Yusuke Nomura, Chie Fukui, Tsuyoshi Kawakami, Toshiyuki Ikeda, Tomokazu Mukai, Toshiyasu Yuba, Ken-Ichi Inamura, Hisatoki Yamaoka, Ken-Ichi Miyazaki, Hitoshi Okazaki, Yuji Haishima   +11 more
doaj   +1 more source

Mode‐of‐Action and Human Relevance Assessment for Diisononyl Phthalate‐Induced Liver Tumors in Rodents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Diisononyl phthalate (DINP) is a high molecular weight phthalate and high production volume chemical. DINP's carcinogenic potential has been investigated in four rodent bioassays, with liver tumors observed in three of the studies. Authoritative assessments have hypothesized that DINP acts through the peroxisome proliferator‐activated receptor
Amanda N. Buerger, Melissa M. Heintz, Laurie C. Haws, Chad M. Thompson   +3 more
wiley   +1 more source

Lentinula edodes Grown on Di(2-ethylhexyl) Phthalate-Containing Media: Mycelial Growth and Enzyme Activities

BioResources, 2015
Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer that is widely used to soften plastic products. It is an endocrine-disrupting compound, widely considered an environmental contaminant that is difficult to remove or degrade. The radial growth rate (ur),
Ángel González-Márquez, Miriam Ahuactzin-Pérez, Carmen Sánchez   +2 more
doaj   +1 more source

Di(2-ethylhexyl)phthalate (DEHP) [PDF]

The Journal of Pediatric Pharmacology and Therapeutics, 2004
Di(2-ethylhexyl) phthalate or DEHP is a colorless, oily liquid and notably, with respect to clinical concerns, is soluble in blood and body fluids containing lipoproteins. Despite being listed as a possible human carcinogen in the 1980's, more recent concerns have focused on its potential toxicity as a result of leaching from medical devices into ...
openaire   +2 more sources

Gas chromatography–mass spectrometry analysis and comprehensive evaluation of antibacterial, antioxidant and anti‐inflammatory properties of Thymus capitatus extracts from Libya

JSFA reports, EarlyView.
Abstract Background The emergence of multidrug‐resistant bacteria necessitates the development of alternative therapeutic approaches. Thymus capitatus, a Mediterranean medicinal plant, has been traditionally used to treat various ailments, but its bioactive potential from Libyan origins remains underexplored.
Ahmed Saeed Kabbashi, Taher Issa Shailabi, Ahlam Mohamed Keshar, Amel Mahmoud Abdrabo, Ahmed Ali Mustafa, Bushray Salih Jabullah, Rama Burhan Hasan, Mona Rafea Mosa, Esraa Radwan Ibrahim, Maryam Mohammed Ibrahim   +9 more
wiley   +1 more source

Combined effect of co-exposure to di (2-ethylhexyl) phthalates and 50-Hz magnetic-fields on promoting human amniotic cells proliferation

Ecotoxicology and Environmental Safety, 2021
Di (2-ethylhexyl) phthalate (DEHP) and extremely low-frequency electromagnetic fields (ELF-EMFs) exist far and wide in our surroundings. Studies have reported that both of DEHP and ELF-EMFs could promote cell proliferation which is related with adverse ...
Liangjing Chen, Anfang Ye, Xiaochen Liu, Jingchun Lu, Qixin Xie, Yixin Guo, Wenjun Sun   +6 more
doaj   +1 more source

Urinary DEHP metabolites and fasting time in NHANES [PDF]

Journal of Exposure Science & Environmental Epidemiology, 2011
Exposure assessment analyses conducted in Europe have concluded that the primary pathway of exposure to di(2-ethylhexyl) phthalate (DEHP) is through the diet. The purpose of this study is to evaluate whether urinary DEHP metabolite data from the 2007-2008 National Health and Nutritional Examination Survey (NHANES) demonstrate relationships with ...
Aylward, Lesa L., Lorber, Matthew, Hays, Sean M.   +2 more
openaire   +5 more sources

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source