Results 51 to 60 of about 276 (148)
Lifespan‐Extending Endogenous Metabolites
Aging Cell, Volume 25, Issue 2, February 2026.Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley +1 more source
A new metabolic path in type 3 rickets
The FEBS Journal, Volume 293, Issue 3, Page 656-659, February 2026.Rickets, a bone disorder, was historically categorised into either nutritional (vitamin D deficiency) or genetic forms involving loss‐of‐function mutations in mineral metabolism. Recently, a new mechanism, type 3 rickets, was discovered to be caused by a gain‐of‐function mutation in CYP3A4 (Ile301Thr).
Toshiya Senda, Yoshihisa Hirota
wiley +1 more source
Journal of Fish Biology, Volume 108, Issue 2, Page 676-693, February 2026.Abstract In the context of current global change, variations in water temperature are one of the environmental conditions with serious consequences for marine life, including reproductive processes. In the small spotted catshark Scyliorhinus canicula, spermatogenesis occurs in spermatocysts composed of synchronously developing germ cells associated ...
Fabian Jeanne +4 more
wiley +1 more source
Compromised Phagosome Maturation Underlies RPE Pathology in Cell Culture and Whole Animal Models of Smith-Lemli-Opitz Syndrome [PDF]
, 2018 Treatment of rats with the cholesterol pathway inhibitor AY9944 produces an animal model of Smith-Lemli-Opitz syndrome (SLOS), an autosomal recessive disease caused by defective cholesterol synthesis.
Fliesler, Steven J. +8 more
core +1 more source
Diagnosis of Smith-Lemli-Opitz syndrome from stored filter paper blood specimens [PDF]
, 2000 BACKGROUND—Smith-Lemli-Opitz (SLO) syndrome is a recessively inheritable metabolic disease with deficiency of cholesterol and accumulation of dehydrocholesterols, caused by a defect in the last step of cholesterol biosynthesis.
Starck, L, Lovgren, A
core +2 more sources
The Chemical Reactivity of Membrane Lipids [PDF]
It is well-known that aqueous dispersions of phospholipids spontaneously assemble into bilayer structures. These structures have numerous applications across chemistry and materials science and form the fundamental structural unit of the biological ...
Duché, Genevieve, Sanderson, John M
core +2 more sources
ChemInform Abstract: A NEW SYNTHESIS OF 7-DEHYDROCHOLESTEROLS
Chemischer Informationsdienst, 1981 AbstractCholesterolacetat (I) wird zu (II) und seinem Stereoisomeren bromiert.
I. D. KULESHA +2 more
core +2 more sources
The Conversion of 7-Dehydrocholesterol into Cholesterol [PDF]
Biochemical Journal, 1966 D C, Wilton, M, Akhtar, K A, Munday
openaire +3 more sources
The Photochemical Dehydrogenation of Ergosterol and 7-Dehydrocholesterol [PDF]
Bulletin of the Chemical Society of Japan, 1939 Abstract Ergopinacone and 7-dehydrocholesterol-pinacone have been prepared by two different methods, viz., the boiling method and the carbon dioxide method. The products obtained by the two methods as well as diacetates and dibenzoates derived from them have been compared.
openaire +1 more source
Cryopreservation and evaluation of Akkaraman ram semen with 7-dehydrocholesterol
Ankara Üniversitesi Veteriner Fakültesi Dergisi, 2018 Bu calisma, tris sulandiricisina 7-dehidrokolesterol ile doyurulmus siklodekstrin bilesimi (7-DCLC) eklenerek dondurmacozdurme sonrasi in vitro sonuclarini degerlendirmek uzere yapildi. Calismada yerli bir irk olarak uc adet Akkaraman koc kullanildi.
İNANÇ, Muhammed Enes +2 more
openaire +3 more sources