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Dehydroepiandrosterone and Addiction
2018Drug addiction has a great negative influence on society, both social and economic burden. It was widely thought that addicts could choose to stop using drugs if only they had some self-control and principles. Nowadays, science has changed this view, defining drug addiction as a complex brain disease that affects behavior in many ways, both biological ...
Gal, Yadid +4 more
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Dehydroepiandrosterone sulfate and dehydroepiandrosterone: neuroactive neurosteroids
Current Opinion in Endocrinology & Diabetes, 2000During the last five years, advances have been made in understanding of the role of dehydroepiandrosterone sulfate (DHEAS) and dehydroepiandrosterone (DHEA) in the central nervous system (CNS). It has become clear that the two molecules can be qualified as neurosteroids and neuroactive steroids.
Yvette Akwa, Etienne-Emile Baulieu
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Dehydroepiandrosterone Replacement Therapy
Seminars in Reproductive Medicine, 2004Dehydroepiandrosterone (DHEA) replacement therapy has attracted considerable attention over recent years. Significant beneficial effects of DHEA replacement have been reported in patients representing the pathophysiological model of complete DHEA deficiency, in other words, adrenal insufficiency (AI). This includes effects on well-being, energy levels,
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Dehydroepiandrosterone and dehydroepiandrosterone sulfate metabolism in human genital skin
Fertility and Sterility, 1990Genital skin samples were obtained from normal women and men to determine the extent of conversion of dehydroepiandrosterone (DHEA) to dihydrotestosterone (DHT) and other androgen metabolites and to assess sulfatase activity. The skin samples were minced and incubated with 3H-DHEA or 3H-dehydroepiandrosterone sulfate (3H-DHEAS) in medium for 1 hour at ...
F R, Kaufman +5 more
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Acta Endocrinologica, 1966
ABSTRACT Four previable foetuses (18th to 20th week of gestation) were perfused with a combination of 14C-labelled dehydroepiandrosterone (DHA) and 3H-labelled dehydroepiandrosterone sulphate (DHAS). Approximately 80% of the radioactive material administered was recovered from the various foetal tissues and perfusates.
E, Bolté, N, Wiqvist, E, Diczfalusy
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ABSTRACT Four previable foetuses (18th to 20th week of gestation) were perfused with a combination of 14C-labelled dehydroepiandrosterone (DHA) and 3H-labelled dehydroepiandrosterone sulphate (DHAS). Approximately 80% of the radioactive material administered was recovered from the various foetal tissues and perfusates.
E, Bolté, N, Wiqvist, E, Diczfalusy
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Synthesis of 7α-hydroxy-dehydroepiandrosterone and 7β-hydroxy-dehydroepiandrosterone
Steroids, 2005The fermentation of dehydroepiandrosterone synthesized from the starting material diosgenin using Mucor racemosus produced 7alpha-hydroxy-dehydroepiandrosterone and 7beta-hydroxy-dehydroepiandrosterone. The bioactivity of the microbial metabolites is also discussed. The species M.
Heping, Li +4 more
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Serum Dehydroepiandrosterone Sulfate and Dehydroepiandrosterone Levels in Essential Hypertension
The Journal of Clinical Endocrinology & Metabolism, 1975Serum dehydroepiandrosterone sulfate (DHEAS), dehydroepiandrosterone (DHEA) and cortisol levels were evaluated on 32 normal and 38 hypertensive males in the forties and fifties, selected from among laborers at a camera work. Hypertensive patients showed significantly higher DHEAS levels than normal subjects in the two age groups.
H, Sekihara, N, Osawa, K, Kosaka
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The Journal of Clinical Endocrinology & Metabolism, 1975
In order to quantitate the chronological change in circulating dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DS) levels during the period of sexual maturation, serum DHEA and DS concentration (3-5 PM) in 76 boys and 65 girls (ages 8 to 15) as well as in adult male and female subjects were measured by a specific and sensitive ...
B R, Hopper, S S, Yen
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In order to quantitate the chronological change in circulating dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DS) levels during the period of sexual maturation, serum DHEA and DS concentration (3-5 PM) in 76 boys and 65 girls (ages 8 to 15) as well as in adult male and female subjects were measured by a specific and sensitive ...
B R, Hopper, S S, Yen
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Dehydroepiandrosterone and Dehydroepiandrosterone Sulphate in Atopic Allergy and Chronic Urticaria
Inflammation, 2008The increasing amounts of evidence prove that sex hormones modulate different cells function, including mast cells and lymphocytes. Dehydroepiandrosterone (DHEA) and its sulphate ester (DHEA-S) are both the secretory products of adrenal glands and the most abundant hormones in the systemic circulation of humans, converted then into androgens and ...
Alicja, Kasperska-Zajac +2 more
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Overview of Dehydroepiandrosterone Biosynthesis
Seminars in Reproductive Medicine, 2004The biosynthesis of dehydroepiandrosterone (DHEA) from cholesterol involves only two enzymes, both cytochrome P450s. The conversion of cholesterol to pregnenolone is mediated by cholesterol side-chain cleavage enzyme (CYP11A1), which is found in the mitochondria. The cleavage of pregnenolone to DHEA requires both the 17alpha-hydroxylase and 17,20-lyase
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