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Dehydroepiandrosterone and Cardiovascular Disease
, 2018 The dehydroepiandrosterone and its metabolite, dehydroepiandrosterone sulfate, have been for a long while at the center of interest for endocrinologists and cardiologists. Consolidated data show that the dehydroepiandrosterone and the dehydroepiandrosterone sulfate present protective actions on the cardiovascular system.
Mannella, P. +3 more
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Dehydroepiandrosterone and ageing
Best Practice & Research Clinical Endocrinology & Metabolism, 2004 Abstract Dehydroepiandrosterone (DHEA) is the crucial precursor of human sex steroid synthesis and thus mediates the majority of its effects indirectly, following downstream conversion to sex steroids and other steroids of potentially distinct activity.
Wiebke Arlt, Arlt, Wiebke
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Dehydroepiandrosterone: A neuroactive steroid
Journal of Steroid Biochemistry and Molecular Biology, 2015Dehydroepiandrosterone (DHEA) and its sulfate bound form (DHEAS) are important steroids of mainly adrenal origin. They are produced also in gonads and in the brain. Dehydroepiandrosterone easily crosses the brain-blood barrier and in part is also produced locally in the brain tissue.
L Starka +2 more
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Dehydroepiandrosterone – a neurosteroid
European Journal of Clinical Investigation, 2000Dehydroepiandrosteone (DHEA) and its sulfate ester (DHEAS) are the major secretory products of the human adrenal glands and serve as precursors for both androgenic and estrogenic steroids. DHEA/S concentrations are particularly high in the brain, and DHEA/S and related steroids can be synthesized de novo in brain glial cells.
Friess, E. +3 more
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THE SECRETION OF DEHYDROEPIANDROSTERONE AND DEHYDROEPIANDROSTERONE SULPHATE IN MAN
Journal of Endocrinology, 1973SUMMARY The secretion of dehydroepiandrosterone (DHA) and its sulphate (DHAS) was examined by measuring their concentrations in adrenal venous, gonadal venous, and peripheral venous plasma. Both steroids were secreted by the adrenal cortex and the rate of DHA secretion was higher than that of DHAS in seven out of eight subjects.
E, Nieschlag +5 more
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Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate Dynamics in Obesity
Canadian Journal of Biochemistry, 1975Dehydroepiandrosterone (D) and dehydroepiandrosterone sulfate (DS) dynamics were studied in three obese female subjects following a single injection of [4-14C]D and [7α-3H]-DS tracers. Dynamic parameters were calculated simultaneously by both the urinary and blood method of compartmentalization. Estimates for the urinary secretion and production rates
T, Fehér, L, Halmy
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Dehydroepiandrosterone and Bone
2018In humans, dehydroepiandrosterone (DHEA), secreted mainly from the adrenal cortex, and its sulfate ester, DHEAS, are the most abundant circulating steroids. DHEA/DHEAS possess pleiotropic effects in human aging, bone, metabolic diseases, neurologic function/neurodegenerative diseases, cancer, immune system and disorders, cardiovascular diseases ...
Shuanhu, Zhou, Julie, Glowacki
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Dehydroepiandrosterone in gout
Steroids, 1964Abstract Butte and Marson (1) have reported normal 17-ketosteroid (17-KS) values for patients with gout, while Wolfson et al (2) reported decreased urinary values. Our study indicates that while the total urinary 17-KS of patients with this disease are normal, 3β-hydroxy-androst-5-en-17-one (dehydroepiandrosterone; DHA) could not be detected.
Jiří Sonka +2 more
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SYNTHESIS OF DEHYDROEPIANDROSTERONE AND DEHYDROEPIANDROSTERONE SULPHATE BY THE HUMAN ADRENAL
Journal of Endocrinology, 1975SUMMARY The role of pregnenolone sulphate in adrenal steroid biosynthesis and the ability of the human adrenal gland to synthesize and secrete dehydroepiandrosterone (DHA) and dehydroepiandrosterone sulphate (DHA sulphate) was investigated. The presence of pregnenolone sulphate and DHA sulphate was demonstrated by measuring their concentrations
T W, Doouss, S J, Skinner, R A, Couch
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Transport of dehydroepiandrosterone and dehydroepiandrosterone sulphate into rat hepatocytes
The Journal of Steroid Biochemistry and Molecular Biology, 1995The purpose of the present study was to characterize the transport of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS) into hepatocytes at physiological and pharmacological concentrations. Hepatocytes were isolated from female Sprague-Dawley rats by collagenase perfusion.
S, Reuter, D, Mayer
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