Results 181 to 190 of about 1,128,553 (311)

Genomic and Metabolic Features of the <i>Lactobacillus sakei</i> HRB10 Isolated from Traditional Dry Sausage in Northeast China Based on Whole Genome Sequencing Technology. [PDF]

Foods
Chen Q, Bai Y, Fan Y, Lu J, Sui Y, Kong B, Hu Y.   +6 more
europepmc   +1 more source

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

Advanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su, Meng Yang, Xinfeng Wang, Pa Wu, Zongzhao Zhai   +4 more
wiley   +1 more source

Linking soil enzymes and microbial community dynamics with organic carbon fluctuations for sustaining the soil health. [PDF]

Sci Rep
Negi M, Kumar P, Chauhan A, Sharma S, Sharma HD, Sharma K.   +5 more
europepmc   +1 more source

A BioLiving Periosteum Evokes Centripetal Regeneration in Challenging Bone Defects

Advanced Science, EarlyView.
Large bone defects often suffer from insufficient central healing. This study engineers a BioLiving periosteum that mimics the native structure. It sequentially delivers remote chemical cues and contact physical cues in a signaling‐relay manner, effectively recruiting and guiding endogenous cells toward the defect center.
Yang Shi, Nian Liu, Jingyi Gu, Yinling Wang, Weiye Wang, Zhiwei Ke, Mingjun Xie, Wenjing Jin, Weicheng Kong, Jue Shi, Hui Pan, Yong He, Zhijian Xie   +12 more
wiley   +1 more source

Expression of yeast NADH dehydrogenase and ascidian alternative oxidase affects metabolism and free radical processes in Drosophila. [PDF]

BMC Res Notes
Lushchak O, Gospodaryov D, Yurkevych I, Strilbytska O.   +3 more
europepmc   +1 more source

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Correction for Herpe et al., When alternative becomes essential: The role of mitochondrial glycerol-3-phosphate dehydrogenase. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Identification, functional characterization, and structural analysis of an atypical l-threonate 3-dehydrogenase. [PDF]

J Biol Chem
Watanabe S, Sato H, Yokoi T, Terawaki SI.   +3 more
europepmc   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Aminoadipate-semialdehyde synthase, a potential target for substrate reduction therapy in glutaric aciduria type 1. [PDF]

Sci Rep
Saad C, Jung-Klawitter S, Dimitrov B, Aguilar-Pimentel JA, Becker L, da Silva-Buttkus P, Dragano NRV, Garrett L, Hölter SM, Rathkolb B, Sanz-Moreno A, Spielmann N, Fuchs H, Gailus-Durner V, Schaaf CP, la Marca G, Damiano R, Lefeber DJ, Engelke U, CHARLIE Consortium, de Angelis MH, Houten SM, Kölker S.   +22 more
europepmc   +1 more source