Results 241 to 250 of about 1,128,553 (311)

Promoter Hypermethylation‐Induced Silencing of FXYD1 Drives Breast Cancer Metastasis via DDX5‐Mediated Wnt/β‐Catenin Pathway Activation

Advanced Science, EarlyView.
This study identifies FXYD1 as an epigenetically silenced tumor suppressor in breast cancer. DNA methylation turns off the gene FXYD1 in breast cancer, and low levels predict worse outcomes. Restoring FXYD1 limits breast cancer cells proliferation and metastasis. In the nucleus, FXYD1 recruits the E3 ligase MAEA to K63‐ubiquitinate DDX5 for proteasomal
Ping Wen, Fanli Qu, Long Wang, Qing Shao, Sisi Li, Yang Qin, Dongping Jiang, Senmiao Zhang, Jiangdong Sui, Guanwen Wang, Ningning Zhang, Xiaohua Zeng   +11 more
wiley   +1 more source

Expanding the Genetic Code with Lysine Aminoacylation. [PDF]

J Am Chem Soc
Li X, Gan Q, Fan C.
europepmc   +1 more source

m5C‐Modified tRF3b‐CysGCA‐23 Suppresses Bladder Cancer Malignancy by Repressing H3K18 Lactylation via Stabilizing RBM4

Advanced Science, EarlyView.
In this study, we identified an NSUN6‐dependent m5C‐modified tsRNA, m5C‐tRF3b CysGCA‐23 (mtRC), that is downregulated in BC and inversely correlated with disease progression. Mechanistically, mtRC suppresses BC malignancy by stabilizing RBM4, attenuating glycolysis, and thereby limiting H3K18 lactylation–mediated activation of IL1RAP and VASH2 ...
Xiaoling Ying, Yapeng Huang, Jian Huang, Qinyu Cai, Danni Zhang, Cong Chen, Yuxi Nie, Baotong Yang, Chuan Li, Wenyu Hu, Chang Xiong, Chengcheng Zhang, Ding Ji, Yaomin Liang, Mei Yang, Wenqi Wu, Weidong Ji   +16 more
wiley   +1 more source

LDHA protects vascular endothelial cells from oxidative stress‑induced mitochondrial damage via HIF‑1α activation and glycolytic reprogramming. [PDF]

Mol Med Rep
Dai B, Yang L, Zhang Y, Yu A.
europepmc   +1 more source

Pooled prevalence of Glucose-6-phosphate dehydrogenase deficiency among malaria patients in Ethiopia: a systematic review and meta-analysis. [PDF]

Malar J
Dessie G, Getnet M, Getahun AB, Mengstie TA, Asefa T, Enyew EF, Yewodiaw TK, Endale HT, Endalew HL.   +8 more
europepmc   +1 more source

Identification of the C9-hydrogenase for 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid (9,17-DOHNA) and the 7α-dehydratase essential for initiating β-oxidation of the B-, C-, and D-rings in steroid degradation by <i>Comamonas testosteroni</i> TA441. [PDF]

Appl Environ Microbiol
Horinouchi M.
europepmc   +1 more source

<i>Vpar_1595</i> encodes malate-lactate transhydrogenase: The first step in lactate metabolism within the genus <i>Veillonella</i>. [PDF]

Gut Microbes Rep
Guillaume MC, Branco Dos Santos F.
europepmc   +1 more source

High-performance liquid chromatography screening reveals HbS/β+-thalassemia double heterozygosity as a pediatric muscular dystrophy mimic. [PDF]

Lab Med
López-Medina C, Portell-Rigo IM, González-Iribarren V, González-Oller C, Sánchez-Crespo A, Molina-Arrebola MA.   +5 more
europepmc   +1 more source