Enhanced Natamycin production in Streptomyces gilvosporeus through phosphate tolerance screening and transcriptome-based analysis of high-yielding mechanisms. [PDF]
Wang L+5 more
europepmc +1 more source
This study develops RLS‐2, a high‐affinity aptamer that specifically targets injured podocytes, making it a promising candidate for targeted drug delivery. In vitro, RLS‐2 shows stability, specificity, efficient siRNA delivery via AsiCs, and uptake by podocytes.
Chao Zhou+9 more
wiley +1 more source
Localisation of proline oxidase and Δ-pyrroline-5-carboxylic acid dehydrogenase in rat liver [PDF]
Beisenherz+11 more
core +1 more source
PRKCQ‐AS1 is overexpressed due to transcriptional super‐enhancers. PRKCQ‐AS1 RNA forms a complex with MSI2 protein to induce BMX mRNA stabilization and overexpression, ERK protein phosphorylation and neuroblastoma cell proliferation. Compound NSC617570 blocks PRKCQ‐AS1 binding to MSI2, leading to BMX mRNA disassociation from MSI2 protein, BMX reduction,
Sujanna Mondal+23 more
wiley +1 more source
Modeling Krebs cycle from liver, heart and hepatoma mitochondria, supported Complex I as target for specific inhibition of cancer cell proliferation. [PDF]
Hernández-Esquivel L+8 more
europepmc +1 more source
Extra-adrenal regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1:physiological regulator and pharmacological target for energy partitioning [PDF]
Alberts+14 more
core +1 more source
Parkinson's disease (PD) progression is aggravated by disrupted inter‐organelle contacts, which are influenced by mechanical forces. NanoMassage, 200 nm PEGylated black phosphorus nanosheets, deliver targeted mechanical stimulation to neural cells.
Tianqi Li+12 more
wiley +1 more source
The ability to detach from biofilms in the lung airways prior to transmission to another host is associated with the infectious phenotype of <i>Mycobacterium abscessus</i>. [PDF]
Keefe B+2 more
europepmc +1 more source