Results 31 to 40 of about 1,499,146 (313)

Doctor's Responsibility For Actions of Delaying And Termination of Life Support of Terminal Patients During The Covid-19 Pandemi

open access: yesSASI, 2022
Introduction: Medical action is a doctor's action toward a patient which includes preventive, diagnostic, curative, or rehabilitative measures. The medical action certainly brings legal consequences, so a doctor is legally responsible for the medical ...
Anggraeni Endah Kusumaningrum
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

open access: yesFEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez   +17 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

The VitiTerroir model to simulate the spatial dynamics of vineyards on the long term (1836-2014)

open access: yesCybergeo, 2019
The VitiTerroir project ambitions to develop a model simulating spatial dynamics of vineyards in Centre-Val de Loire region, France. We study these dynamics in the long (several centuries), medium and short term, using historical sources (administrative ...
Adrien Lammoglia   +2 more
doaj   +1 more source

Synchronization of Caputo fractional neural networks with bounded time variable delays

open access: yesOpen Mathematics, 2021
One of the main problems connected with neural networks is synchronization. We examine a model of a neural network with time-varying delay and also the case when the connection weights (the influential strength of the jjth neuron to the iith neuron) are ...
Almeida Ricardo   +2 more
doaj   +1 more source

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

open access: yesFEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

Multiple Hopf Bifurcations of Four Coupled van der Pol Oscillators with Delay

open access: yesMathematics, 2023
In this paper, a system of four coupled van der Pol oscillators with delay is studied. Firstly, the conditions for the existence of multiple periodic solutions of the system are given.
Liqin Liu, Chunrui Zhang
doaj   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

open access: yesFEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile   +8 more
wiley   +1 more source

Delay aversion [PDF]

open access: yesTheoretical Economics, 2005
We address the following question: When can one person properly be said to be more delay averse than another? In reply, several (nested) comparison methods are developed. These methods yield a theory of delay aversion which parallels that of risk aversion.
Benoît, Jean-Pierre, Ok, Efe A.
openaire   +2 more sources

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

open access: yesFEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke   +2 more
wiley   +1 more source

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