Results 1 to 10 of about 29,405 (251)

Exposure to heavy metals, bisphenol A, and phthalates: Implications for precocious or delayed puberty. [PDF]

PLoS ONE
This study examined the associations between exposure to heavy metals, bisphenol A (BPA), and phthalates and precocious or delayed puberty. This study was a cross-sectional study using the data obtained from the Korea Environmental Exposure and Health ...
Seung-Ah Choe, Eunjung Kim, Mina Ha
doaj   +2 more sources

Clinical approach to the male with delayed puberty [PDF]

Archives of Endocrinology and Metabolism
Disorders of pubertal onset and progression are a common cause for referral to paediatric endocrinologists, with delayed puberty in males being particularly frequent. Pubertal development depends on the hypothalamic-pituitary-testicular (HPT) axis, which
Rodolfo A. Rey, Romina P. Grinspon, Sebastián Castro   +2 more
doaj   +2 more sources

Delayed puberty [PDF]

Journal of Clinical Endocrinology & Metabolism, 1996
Delayed puberty can be defined as the absence of any signs of puberty in subjects that have attained an age at the upper limit (+2DS) for the onset of puberty, that means 13 years in girls and 14 years in boys. The causes of delayed puberty can be classified into three groups, functional temporary impairment in gonadotropin and sex steroid secretion ...
ANTONIAZZI, Franco, ZAMBONI, Giorgio, TATO', Luciano   +2 more
openaire   +5 more sources

Delayed Puberty and Its Association With Hormonal Changes in Children With Chronic Renal Insufficiency

Acta Medica Iranica, 2022
Chronic kidney diseases affect sex hormones, and thus it is now hypothesized abnormal puberty phenomenon in adolescents suffering renal failure. The primary study endpoint was to assess the frequency of disorders related to the clinical incidence of ...
Davood Amirkashani, Nakisa Hooman, Mohaddese Shahidzadeh   +2 more
doaj   +1 more source

Frasier Syndrome: A 15-Year-Old Phenotypically Female Adolescent Presenting with Delayed Puberty and Nephropathy

Children, 2023
Frasier syndrome (FS) is a rare inherited disorder characterized by gonadal dysgenesis and progressive nephropathy, resulting from mutations in the intron 9 splice donor site of the Wilms tumor 1 (WT1) gene. It is associated with male gonadal dysgenesis (
Qing Shao, Xinglei Xie, Jia Geng, Xiaoling Yang, Wei Li, Yuwei Zhang   +5 more
doaj   +1 more source

Congenital hypogonadotropic hypogonadism: from clinical characteristics to genetic aspects [PDF]

Precision and Future Medicine, 2021
Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder caused by a deficiency in gonadotropin-releasing hormone (GnRH). CHH is characterized by delayed puberty and/or infertility; this is because GnRH is the main component of the hypothalamic ...
Ahreum Kwon, Ho-Seong Kim
doaj   +1 more source

Insulin-like peptide 3 (INSL3) in congenital hypogonadotrophic hypogonadism (CHH) in boys with delayed puberty and adult men

Frontiers in Endocrinology, 2022
BackgroundDelayed puberty in males is almost invariably associated with constitutional delay of growth and puberty (CDGP) or congenital hypogonadotrophic hypogonadism (CHH).
Ali Abbara, Ali Abbara, Kanyada Koysombat, Maria Phylactou, Maria Phylactou, Pei Chia Eng, Pei Chia Eng, Sophie Clarke, Sophie Clarke, Alexander N. Comninos, Alexander N. Comninos, Lisa Yang, Lisa Yang, Chioma Izzi-Engbeaya, Chioma Izzi-Engbeaya, Simon Hanassab, Simon Hanassab, Neil Smith, Channa N. Jayasena, Channa N. Jayasena, Cheng Xu, Cheng Xu, Richard Quinton, Richard Quinton, Nelly Pitteloud, Nelly Pitteloud, Gerhard Binder, Ravinder Anand-Ivell, Richard Ivell, Waljit S. Dhillo, Waljit S. Dhillo   +30 more
doaj   +1 more source

Genetic Evaluation of Patients With Delayed Puberty and Congenital Hypogonadotropic Hypogonadism: Is it Worthy of Consideration?

Frontiers in Endocrinology, 2020
Delayed puberty is a common reason of pediatric endocrinological consultation. It is often a self-limited (or constitutional) condition with a strong familial basis. The type of inheritance is variable but most commonly autosomal dominant.
Adalgisa Festa, Giuseppina Rosaria Umano, Emanuele Miraglia del Giudice, Anna Grandone   +3 more
doaj   +1 more source

Whole exome sequencing identifies deleterious rare variants in CCDC141 in familial self-limited delayed puberty

npj Genomic Medicine, 2021
Developmental abnormalities of the gonadotropin-releasing hormone (GnRH) neuronal network result in a range of conditions from idiopathic hypogonadotropic hypogonadism to self-limited delayed puberty.
Tansit Saengkaew, Gerard Ruiz-Babot, Alessia David, Alessandra Mancini, Katia Mariniello, Claudia P. Cabrera, Michael R. Barnes, Leo Dunkel, Leonardo Guasti, Sasha R. Howard   +9 more
doaj   +1 more source

Key features of puberty onset and progression can help distinguish self-limited delayed puberty from congenital hypogonadotrophic hypogonadism

Frontiers in Endocrinology, 2023
IntroductionDelayed puberty (DP) is a frequent concern for adolescents. The most common underlying aetiology is self-limited DP (SLDP). However, this can be difficult to differentiate from the more severe condition congenital hypogonadotrophic ...
Yuri Aung, Yuri Aung, Vasilis Kokotsis, Kyla Ng Yin, Kausik Banerjee, Gary Butler, Gary Butler, Mehul T. Dattani, Mehul T. Dattani, Mehul T. Dattani, Paul Dimitri, Leo Dunkel, Claire Hughes, Michael McGuigan, Márta Korbonits, Márta Korbonits, George Paltoglou, Sophia Sakka, Pratik Shah, Pratik Shah, Helen L. Storr, Helen L. Storr, Ruben H. Willemsen, Sasha R. Howard, Sasha R. Howard   +24 more
doaj   +1 more source