Molecular basis of normal and pathological puberty: from basic mechanisms to clinical implications.
The Lancet Diabetes and Endocrinology, 2023 Puberty is a major maturational event; its mechanisms and timing are driven by genetic determinants, but also controlled by endogenous and environmental cues.
J. Argente +6 more
semanticscholar +1 more source
Pubertal presentation in seven patients with congenital adrenal hyperplasia due to P450 Oxidoreductase deficiency [PDF]
, 2010 Context: P450 oxidoreductase (POR) is a crucial electron donor to all microsomal P450 cytochrome (CYP) enzymes including 17α-hydroxylase (CYP17A1), 21-hydroxylase (CYP21A2) and P450 aromatase.
Adachi +59 more
core +2 more sources
Growth to early adulthood following extremely preterm birth: the EPICure study. [PDF]
, 2020 OBJECTIVE: To investigate growth trajectories from age 2.5 to 19 years in individuals born before 26 weeks of gestation (extremely preterm; EP) compared with term-born controls.
Beckmann, J +5 more
core +2 more sources
Ablating astrocyte insulin receptors leads to delayed puberty and hypogonadism in mice
PLoS Biology, 2019 Insulin resistance and obesity are associated with reduced gonadotropin-releasing hormone (GnRH) release and infertility. Mice that lack insulin receptors (IRs) throughout development in both neuronal and non-neuronal brain cells are known to exhibit ...
Iyad H Manaserh +5 more
semanticscholar +1 more source
Sex assignment in conditions affecting sex development [PDF]
, 2017 The newborn infant with atypical genitalia presents a challenging clinical scenario and requires expert input. There have been appreciable advances in our knowledge of the underlying causes that may lead to a mere difference or a more serious disorder of
Ahmed, S. Faisal, Markosyan, Renata
core +1 more source
Constitutional delay of growth and puberty in boys: review
Mìžnarodnij Endokrinologìčnij Žurnal, 2019 The review focuses on the diagnosis, clinical and general therapeutic approach to constitutional growth and delayed puberty and hypogonadotrophic hypogonadism in men, which are difficult to distinguish. Clinical history and physical examination should be
A.B. Grossman +4 more
doaj +1 more source
Zhongguo gonggong weisheng, 2022 ObjectiveTo explore the relationship between puberty timing and parental age at childbirth among primary and secondary students and in Beijing, and to provide a reference for further comprehending puberty development of children and adolescents ...
Zu-hong ZHANG, Tian-jiao CHEN, Jun MA
doaj +1 more source
PRACTICE VARIATION IN THE MANAGEMENT OF GIRLS AND BOYS WITH DELAYED PUBERTY.
Endocrine Practice, 2019 Objective: Delayed puberty is a common condition, and typical management includes "watchful waiting" and/or sex-steroid therapy. We sought to characterize treatment practices and to assess provider comfort with the management of delayed puberty in girls ...
Jia Zhu +6 more
semanticscholar +1 more source
Maternal pre-pregnancy obesity and timing of puberty in sons and daughters: a population-based cohort study. [PDF]
, 2019 BackgroundIn many countries, an increased prevalence of obesity in pregnancy has coincided with a declining pubertal age. We aimed to explore the potential effect of maternal pre-pregnancy overweight and obesity on timing of puberty in sons and daughters.
Arah, Onyebuchi A +7 more
core +2 more sources
Frequency of Delayed Puberty in Boys with Contemporary Management of Duchenne Muscular Dystrophy
JCRPEINTRODUCTION: Delayed puberty is thought to be common in boys with Duchenne muscular dystrophy (DMD) treated with long term oral glucocorticoid. The aim of this study was to report the frequency of delayed puberty in DMD from examination by a paediatric ...
Sarah McCarrison +6 more
doaj +1 more source