Results 61 to 70 of about 540,529 (281)

Developmental differences in cortical bone structure in chimpanzee and human femora reflect early locomotor independence in humans

The Anatomical Record, EarlyView.
Abstract The cortical bone structure of long bone diaphyses changes throughout growth via skeletal modeling and has important implications for bone strength and structural integrity. Ontogenetic trends in diaphyseal structure have been identified in both chimpanzees and humans but it is not yet clear how these trends compare given notable differences ...
Karen R. Swan, Rachel Ives, Zewdi J. Tsegai, Louise T. Humphrey   +3 more
wiley   +1 more source

A potential mechanism for the sexual dimorphism in the onset of puberty and incidence of idiopathic central precocious puberty in children: Sex-specific kisspeptin as an integrator of puberty signals

Frontiers in Endocrinology, 2012
The major determinants of the variability in pubertal maturation are reported to be genetic and inherited. Nonetheless, nutritional status contributes significantly to this variability. Malnutrition delays puberty whereas obesity has been associated to a
Suzy eBianco, Suzy eBianco
doaj   +1 more source

Craniofacial growth, modeling, and estimation of milestones

The Anatomical Record, EarlyView.
Abstract Understanding craniofacial growth is foundational for research into intra‐ and interspecies variation, evolution, and clinical care. The Craniofacial Growth Consortium Study (CGCS), combines cephalographs from historical growth studies to create a dense longitudinal record of growth from 6 to 22 years of age.
Richard J. Sherwood, Dana L. Duren, Christina L. Holzhauser, Hee Soo Oh, Manish Valiathan, Kieran P. McNulty, Kevin M. Middleton   +6 more
wiley   +1 more source

Hypothyroidism-associated testicular enlargement: is it a form of precocious puberty or not? A case report

The Turkish Journal of Pediatrics, 2011
In children with untreated hypothyroidism, the onset of puberty is usually delayed, but gonadotropin-independent precocious puberty may occur in children with severe hypothyroidism of long duration.
Ihsan Esen, Fatma Demirel
doaj  

Treatment of Peripheral Precocious Puberty

, 2016
There are many etiologies of peripheral precocious puberty (PPP) with diverse manifestations resulting from exposure to androgens, estrogens, or both. The clinical presentation depends on the underlying process and may be acute or gradual.
Schoelwer, Melissa, Erica A. Eugster, Melissa Schoelwer, Eugster, Erica A.   +3 more
core   +1 more source

Role of IGSF10 mutations in self-limited delayed puberty [PDF]

, 2016
Background Abnormal timing of puberty affects over 4% of adolescents and is associated with adverse health and psychosocial outcomes. Previous studies estimate that 60–80% of variation in the timing of pubertal onset is genetically determined.
Sternberg, M, Warren, H, Gerard Ruiz-Babot, Valentina Andre, Barnes, M, Michael Sternberg, Wehkalampi, K, Andre, V, Sasha Howard, Helen Storr, Michael Barnes, Leo Dunkel, Leo Guasti, David, A, Cabrera, C, Mancini, A, Louise Metherell, Alessandra Mancini, Helen Warren, Karoliina Wehkalampi, Alessia David, Guasti, L, Anna Cariboni, Gothilf, Y, Ruiz-Babot, G, Yoav Gothilf, Metherell, L, Claudia Cabrera, Howard, S, Cariboni, A, Storr, H, Dunkel, L   +31 more
core   +1 more source

A White Paper on Advancing Long‐Acting Therapeutics for Maternal and Pediatric Health by Bridging Gaps in Clinical Research, Access and Regulation

Clinical Pharmacology &Therapeutics, EarlyView.
As use cases for long‐acting therapeutics expand across clinical indications, there is a critical need to ensure the inclusion of women who are pregnant or breastfeeding, infants and children—populations with a historical gap in the availability of interventions already approved for use in adults.
Moherndran Archary, Robert Bies, Osei Boateng, Rachel Daley, Pierre Gashema, Mili Karina, Emily Njuguna, Sharon Nachman, Nathaniel Nkrumah, Carolyne Odula, Andrew Owen, Ethel D. Weld, Prajith Venkatasubramanian, Adeniyi Olagunju, on behalf of the Community of Practice for Long‐acting Therapeutics for Maternal and Paediatric Health, Rana Abutaima, Dorothy Akongo, Abdulnaser Alsharaa, Moherndran Archary, Shakir Atoyebi, Benoit Bestgen, Robert Bies, Osei Boateng, Andrew Butler, Edmund Capparelli, Rachel Daley, Layla Davies, Joelle Dountio, Henry Enzama, Pierre Gashema, Katila George, Dan Hawcutt, Rene Holm, Patrick Gad Iradukunda, Elodie Jambert, Mili Karina, Linda Lewis, Grace Miheso, Sebastien Morin, Andrew Morrison, Sharon Nachman, Shadia Nakalema, Emily Njunga, Nathaniel Nkrumah, Carolyne Odula‐Obonyo, Brenda Okware, Adeniyi Olagunju, Andrew Owen, Martina Penazzato, Natella Rakhmanina, Mphako Brighton Ratlabyana, Rachel Scott, Kimberly Struble, Andre‐Marie Tchouatieu, Catherine Unsworth, Prajith Venkatasubramanian, Catriona Waitt, Ethel Weld, Janine Winterbottom, Leena Zino   +59 more
wiley   +1 more source

Juvenile Granulosa Cell Tumor with Elevated Peripheral Interleukin-6 Level Shows Prolonged Fever and Delayed Puberty [PDF]

Juvenile granulosa cell tumor (JGCT), classified as a sex cord-stromal tumor, is a rare neoplasm. This is an instructive case report of JGCT accompanied by augmented interleukin (IL)-6 secretion.
17268, 17269, Okuno, Keisuke, Nishimura, Rei, Kanzaki, Susumu, Kuwamoto, Satoshi, 100000360, 90224873, 791, 60229226, 572, 1855, 100000861, Harada, Tasuku, 100000223, 100000421, 1311, 100001118, 60567189, Horie, Yasushi, 2649, Komatsu, Hiroaki, Ueyama, Jun-ichi, 17270, 17271, Sano, Hiroshi, 2919, 100000139, 40218649, Yoneda, Naohiro   +29 more
core   +1 more source

Evaluation of Serum Leptin Levels and Growth in Patients with β-Thalassaemia Major

Anemia, 2016
Background. Iron deposition in the body can damage the endocrine glands of patients with β-thalassaemia major (β-TM). Leptin plays a key role in the regulation of appetite, body fat mass, and endocrine function. Objectives.
Lamia Mustafa Al-Naama, Meaad Kadum Hassan, Muhannad Maki Abdul Karim   +2 more
doaj   +1 more source

Community as Medicine: A Qualitative Exploration of Meaningful Social Support and Health for Trans‐ and Gender‐Diverse People in England

European Journal of Social Psychology, EarlyView.
ABSTRACT The poor mental and physical health of trans‐ and gender‐diverse (TGD) young people is well established and commonly attributed to gender minority stress. Although recent research has shown that social support can mitigate these effects, less attention has been paid to the psychological processes through which this occurs.
Chase Staras, Juliet Wakefield, Daragh McDermott, Bethany Jones   +3 more
wiley   +1 more source