Results 21 to 30 of about 2,220,873 (330)

LGR4 deficiency results in delayed puberty through impaired Wnt/β-catenin signaling

JCI Insight, 2020
The initiation of puberty is driven by an upsurge in hypothalamic gonadotropin-releasing hormone (GnRH) secretion. In turn, GnRH secretion upsurge depends on the development of a complex GnRH neuroendocrine network during embryonic life. Although delayed
A. Mancini, S. Howard, F. Marelli, C. Cabrera, M. Barnes, M. Sternberg, Morgane Leprovots, Irene Hadjidemetriou, E. Monti, A. David, K. Wehkalampi, R. Oleari, A. Lettieri, V. Vezzoli, G. Vassart, A. Cariboni, M. Bonomi, M. Garcia, L. Guasti, L. Dunkel   +19 more
semanticscholar   +1 more source

Psychosexual effects resulting from delayed, incomplete, or absent puberty.

Current Opinion in Endocrine and Metabolic Research, 2020
Puberty is a remarkable period of postnatal development culminating in reproductive capacity. Biological changes of puberty are accompanied by social and emotional changes including psychosexual development.
A. Dwyer
semanticscholar   +1 more source

Delayed and Precocious Puberty: Genetic Underpinnings and Treatments.

Endocrinology and metabolism clinics of North America (Print), 2020
Delayed puberty may signify a common variation of normal development, or indicate the presence of a pathologic process. Constitutional delay of growth and puberty is a strongly familial type of developmental pattern and accounts for the vast majority of ...
Anisha Gohil, E. Eugster
semanticscholar   +1 more source

Testosterone undecanoate treatment for muscle weakness in a male with hypogonadotropic hypogonadism delayed puberty: A case report

JKKI (Jurnal Kedokteran dan Kesehatan Indonesia), 2022
Puberty is a series of physical development and sexual maturation that aims to achieved reproductive capacity. The hypothalamic-pituitary-gonadal (HPG) axis has an important role in the normal process of puberty.
Dicky Moch Rizal, Nandia Septiyorini
doaj   +1 more source

Substance P regulates puberty onset and fertility in the female mouse [PDF]

, 2015
Puberty is a tightly regulated process that leads to reproductive capacity. Kiss1 neurons are crucial in this process by stimulating GnRH, yet how Kiss1 neurons are regulated remains unknown. Substance P (SP), an important neuropeptide in pain perception,
Carroll, R.S., Gill, J.C., Kaiser, U.B., Maguire, C.A., Navarro, V.M., Simavli, Serap Aynur, Thompson, I.R., Wolfe, A.   +7 more
core   +1 more source

Environmental Exposures during Puberty: Window of Breast Cancer Risk and Epigenetic Damage. [PDF]

, 2020
During puberty, a woman's breasts are vulnerable to environmental damage ("window of vulnerability"). Early exposure to environmental carcinogens, endocrine disruptors, and unhealthy foods (refined sugar, processed fats, food additives) are hypothesized ...
Aljaber, Dana, Au, Dawn, Benmarhnia, Tarik, Cardiff, Robert D, Chavez, Tanya, Dietze, Eric C, Doan, Stacey, Jankowska, Marta M, Jones, Veronica, McCune, Jeannine S, Natarajan, Rama, Nunez, Alan, Resto, Cristal, Sanchez, Angelica, Seewaldt, Victoria L, Serrano, Mayra, Sistrunk, Christopher, Thai, Christine, Tomsic, Jerneja, Yang, Jiue-An   +19 more
core   +1 more source

Enhanced at puberty 1 (EAP1) is a new transcriptional regulator of the female neuroendocrine reproductive axis [PDF]

, 2007
The initiation of mammalian puberty and the maintenance of female reproductive cycles are events controlled by hypothalamic neurons that secrete the decapeptide gonadotropin-releasing hormone (GnRH).
Sabine Heger, Claudio Mastronardi, Gregory A. Dissen, Alejandro Lomniczi, Ricardo Cabrera, Christian L. Roth, Heike Jung, Francesco Galimi, Wolfgang Sippell, Sergio R. Ojeda, Ojeda, Terasawa, Dungan, DeFazio, Krewson, Seminara, Palmert, de Vries, Ojeda, Davidson, Basso, Rampazzo, Sutton, Martin, Bhanot, Ebling, Morris-Desbois, Burkhard, Sauring, Freemont, Waterman, Bridge, Tiscornia, Sledz, Simerly, Farooqi, Ahima, Shimono, Childs, Treacy, Ma, Ojeda, Kimura, Lee, Mastronardi, Ojeda, Watanabe, Nelson, Prevot, Dissen, Dissen, Shahab, Miyagishi, Singer, Chen, Naldini, Kootstra   +56 more
core   +1 more source

Evo-devo of human adolescence: beyond disease models of early puberty [PDF]

, 2013
Despite substantial heritability in pubertal development, much variation remains to be explained, leaving room for the influence of environmental factors to adjust its phenotypic trajectory in the service of fitness goals.
A Templeton, AB Arquitt, AB Migliano, AK Pesonen, AS Parent, B Bogin, B Campbell, BH Smith, BJ Ellis, BJ Ellis, BJ Ellis, BJ Ellis, BS Zemel, C Ankarberg Lindgren, C Cooper, C Tardieu, CC Chen, CL Sisk, F Deng, GB Cutler Jr, GB Muller, GE Weisfeld, J Belsky, J Belsky, J Belsky, J Belsky, J Belsky, J Belsky, J Belsky, J Belsky, J Belsky, J Bowlby, J Bowlby, J James, J Tinggaard, Jay Belsky, JC Wingfield, JL Locke, JM Tither, KB Simondon, KK Ong, KK Ong, KO Klein, L Aksglaede, LA Proos, M Celio, M Del Giudice, M Krstevska-Konstantinova, M Mead, M Suzuki, ME Pembrey, MR Palmert, N Howell, NM Cameron, PD Gluckman, PD Kroboth, PJ Hunt, RG Westendorp, S White, SB Manuck, SC Stearns, W Arlt, W Copeland, WT Boyce, Z Hochberg, Z Hochberg, Z Hochberg, Z Hochberg, Z Hochberg, Ze'ev Hochberg   +69 more
core   +2 more sources

Mutational analysis of DAX1 in patients with hypogonadotropic hypogonadism or pubertal delay [PDF]

, 1999
Although delayed puberty is relatively common and often familial, its molecular and pathophysiologic basis is poorly understood. In contrast, the molecular mechanisms underlying some forms of hypogonadotropic hypogonadism (HH) are clearer, following the ...
Achermann, JC, Bick, DP, Crowley, WF, Gu, WX, Habiby, RL, Hindmarsh, PC, Jameson, JL, Kotlar, TJ, Layman, LC, Meeks, JJ, Sabacan, LP, Seminara, SB, Sherins, RJ   +12 more
core   +1 more source

Delayed Puberty in Girls with Primary Amenorrhea: A Report of Cases

Journal of Biomedicine and Translational Research, 2021
Background:Female puberty starts when the pituitary hormone producing follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which will stimulate the ovaries to produce estrogen.
Fatinah Shahab, Inu Mulyantoro, Hary Tjahjanto, Tri Indah Winarni, Sultana MH Faradz   +4 more
doaj   +1 more source