Results 11 to 20 of about 31,437 (284)

Delayed puberty [PDF]

Journal of Clinical Endocrinology & Metabolism, 1996
Delayed puberty can be defined as the absence of any signs of puberty in subjects that have attained an age at the upper limit (+2DS) for the onset of puberty, that means 13 years in girls and 14 years in boys. The causes of delayed puberty can be classified into three groups, functional temporary impairment in gonadotropin and sex steroid secretion ...
ANTONIAZZI, Franco, ZAMBONI, Giorgio, TATO', Luciano   +2 more
core   +6 more sources

The Genetic Basis of Delayed Puberty [PDF]

Frontiers in Endocrinology, 2019
Delayed pubertal onset has many etiologies, but on average two-thirds of patients presenting with late puberty have self-limited (or constitutional) delayed puberty. Self-limited delayed puberty often has a strong familial basis.
Sasha R. Howard
doaj   +2 more sources

Genetic Evaluation of Patients With Delayed Puberty and Congenital Hypogonadotropic Hypogonadism: Is it Worthy of Consideration?

Frontiers in Endocrinology, 2020
Delayed puberty is a common reason of pediatric endocrinological consultation. It is often a self-limited (or constitutional) condition with a strong familial basis. The type of inheritance is variable but most commonly autosomal dominant.
Adalgisa Festa, Giuseppina Rosaria Umano, Emanuele Miraglia del Giudice, Anna Grandone   +3 more
doaj   +2 more sources

Frasier Syndrome: A 15-Year-Old Phenotypically Female Adolescent Presenting with Delayed Puberty and Nephropathy

Children, 2023
Frasier syndrome (FS) is a rare inherited disorder characterized by gonadal dysgenesis and progressive nephropathy, resulting from mutations in the intron 9 splice donor site of the Wilms tumor 1 (WT1) gene. It is associated with male gonadal dysgenesis (
Qing Shao, Xinglei Xie, Jia Geng, Xiaoling Yang, Wei Li, Yuwei Zhang   +5 more
doaj   +2 more sources

Exposure to heavy metals, bisphenol A, and phthalates: Implications for precocious or delayed puberty. [PDF]

PLoS ONE
This study examined the associations between exposure to heavy metals, bisphenol A (BPA), and phthalates and precocious or delayed puberty. This study was a cross-sectional study using the data obtained from the Korea Environmental Exposure and Health ...
Seung-Ah Choe, Eunjung Kim, Mina Ha
doaj   +2 more sources

Whole exome sequencing identifies deleterious rare variants in CCDC141 in familial self-limited delayed puberty

npj Genomic Medicine, 2021
Developmental abnormalities of the gonadotropin-releasing hormone (GnRH) neuronal network result in a range of conditions from idiopathic hypogonadotropic hypogonadism to self-limited delayed puberty.
Tansit Saengkaew, Gerard Ruiz-Babot, Alessia David, Alessandra Mancini, Katia Mariniello, Claudia P. Cabrera, Michael R. Barnes, Leo Dunkel, Leonardo Guasti, Sasha R. Howard   +9 more
doaj   +2 more sources

Clinical approach to the male with delayed puberty [PDF]

Archives of Endocrinology and Metabolism
Disorders of pubertal onset and progression are a common cause for referral to paediatric endocrinologists, with delayed puberty in males being particularly frequent. Pubertal development depends on the hypothalamic-pituitary-testicular (HPT) axis, which
Rodolfo A. Rey, Romina P. Grinspon, Sebastián Castro   +2 more
doaj   +2 more sources

Insulin-like peptide 3 (INSL3) in congenital hypogonadotrophic hypogonadism (CHH) in boys with delayed puberty and adult men [PDF]

Frontiers in Endocrinology, 2022
BackgroundDelayed puberty in males is almost invariably associated with constitutional delay of growth and puberty (CDGP) or congenital hypogonadotrophic hypogonadism (CHH).
Ali Abbara, Ali Abbara, Kanyada Koysombat, Maria Phylactou, Maria Phylactou, Pei Chia Eng, Pei Chia Eng, Sophie Clarke, Sophie Clarke, Alexander N. Comninos, Alexander N. Comninos, Lisa Yang, Lisa Yang, Chioma Izzi-Engbeaya, Chioma Izzi-Engbeaya, Simon Hanassab, Simon Hanassab, Neil Smith, Channa N. Jayasena, Channa N. Jayasena, Cheng Xu, Cheng Xu, Richard Quinton, Richard Quinton, Nelly Pitteloud, Nelly Pitteloud, Gerhard Binder, Ravinder Anand-Ivell, Richard Ivell, Waljit S. Dhillo, Waljit S. Dhillo   +30 more
doaj   +2 more sources

Delayed Puberty in Girls with Primary Amenorrhea: A Report of Cases

Journal of Biomedicine and Translational Research, 2021
Background:Female puberty starts when the pituitary hormone producing follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which will stimulate the ovaries to produce estrogen.
Fatinah Shahab, Inu Mulyantoro, Hary Tjahjanto, Tri Indah Winarni, Sultana MH Faradz   +4 more
doaj   +3 more sources

Testosterone undecanoate treatment for muscle weakness in a male with hypogonadotropic hypogonadism delayed puberty: A case report

JKKI (Jurnal Kedokteran dan Kesehatan Indonesia), 2022
Puberty is a series of physical development and sexual maturation that aims to achieved reproductive capacity. The hypothalamic-pituitary-gonadal (HPG) axis has an important role in the normal process of puberty.
Dicky Moch Rizal, Nandia Septiyorini
doaj   +3 more sources