Results 171 to 180 of about 1,254,509 (299)

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Kynurenic acid signaling expands in human and nonhuman primates and impairs dorsolateral prefrontal cortical cognition that is key to mental illness. [PDF]

Mol Psychiatry
Yang S, Datta D, Krienen FM, Woo E, May A, Anderson GM, Galvin VC, Gonzalez-Burgos G, Lewis DA, Ling E, McCarroll SA, Arnsten AF, Wang M.   +12 more
europepmc   +1 more source

Effects of Biological Sex and Age on Cerebrospinal Fluid Markers—A Retrospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebrospinal fluid (CSF) analysis is a key diagnostic tool for neurological diseases. To date, only a few studies have investigated in larger cohorts the effect of age and biological sex on diagnostic markers extracted from CSF. Methods For this retrospective observational study, 4163 CSF findings (2012–2020) were evaluated.
Isabel‐Sophie Hafer, Simon Faissner, Ralf Gold, Aiden Haghikia   +3 more
wiley   +1 more source

Diagnostic evaluation of pleural effusion in patients with non-small lung cancer affects time to diagnosis and treatment initiation. [PDF]

J Thorac Dis
Lin J, Shojaee S, Ali B, Bassett R, Ost D, Grosu H.   +5 more
europepmc   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

High-gain CRLH vivaldi antenna for enhanced channel performance at Ku-band communication systems. [PDF]

Sci Rep
Ali MM, Segura EM, Elwi TA.
europepmc   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Tuning lipid accumulation and fitness of motile algae via hydrodynamic cues. [PDF]

Front Bioeng Biotechnol
Kakavand N, Sengupta A.
europepmc   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Does active case finding detect TB early in programme settings? A national-level study in India. [PDF]

Public Health Action
Shewade HD, Kiran Pradeep S, Ravichandran P, Kiruthika G, Shah AN, Vadera B, Roddawar V, Mattoo SK, Iyer S, Tumu D, Chowdhury A, Devika S, Chadwick J, Vaidya RR, Singh P, Panda SK, Baig MA, Suma KV, Suleka M, Digal AK, Banerjee D, Prasanna ML, Waghela DY, Krishnaraj A, Kashyap P, Parmar JS, Mishra CK, Das S, Kumar A, Kumar A, Yadav S, Chetry S, Kumar A, Pathak M, Singh S, Tabrez S, Mehra P, Ramesh S, Bishnu B, Mahesh G, Rajesham A, Mishra BK, Chandra Tripathi U, Khayyam KU, Rade K, Rao R, Murhekar MV.   +46 more
europepmc   +1 more source