Results 31 to 40 of about 43,728 (258)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Equivalent systems for differential equations with polynomially distributed delay

Mathematical and Computer Modelling of Dynamical Systems
We consider delay differential equations with a polynomially distributed delay. We derive an equivalent system of delay differential equations, which includes just two discrete delays.
Roland Pulch
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Linear Analysis of an Integro-Differential Delay Equation Model

International Journal of Differential Equations, 2018
This paper presents a computational study of the stability of the steady state solutions of a biological model with negative feedback and time delay. The motivation behind the construction of our system comes from biological gene networks and the model ...
Anael Verdugo
doaj   +1 more source

Computational method for singularly perturbed delay differential equations with twin layers or oscillatory behaviour

Ain Shams Engineering Journal, 2015
In this paper, we have presented a computational method for solving singularly perturbed delay differential equations with twin layers or oscillatory behaviour. In this method, the original second order singularly perturbed delay differential equation is
D. Kumara Swamy, K. Phaneendra, A. Benerji Babu, Y.N. Reddy   +3 more
doaj   +1 more source

Quintic B-Spline Technique for Numerical Treatment of Third Order Singular Perturbed Delay Differential Equation [PDF]

International Journal of Mathematical, Engineering and Management Sciences, 2019
In this paper, a class of third order singularly perturbed delay differential equation with large delay is considered for numerical treatment. The considered equation has discontinuous convection-diffusion coefficient and source term.
Mandeep Kaur Vaid, Geeta Arora
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

On stability and boundedness of solutions of a certain fourth-order delay differential equation

International Journal of Mathematics and Mathematical Sciences, 1989
Using a Razumikhin - type theorem, we deduce sufficient conditions that guarantee the uniform asymptotic stability and boundedness of solutions of a scalar real fourth-order delay differential equation.
Emmanuel O. Okoronkwo
doaj   +1 more source